Abstract
Parkinson’s disease (PD) is the second most common severe neurodegenerative disorder that is characterized by progressive degeneration of dopaminergic neurons (DA neurons) in the substantia nigra pars compacta (SNpc) region of the brain. In the present study, we investigated the effects of the synthetic regulatory peptides Semax (analog of an ACTH 4-10 fragment (ACTH4-10)) and Selank (analog of immunomodulatory taftsin) on behavior of rats with 6-hydroxidopamine (6-OHDA) induced PD-like parkinsonism. It was showed that both peptides did not affect motor activity of rats in elevated cross shaped maze and passive defensive behavior of the animals. At the same time, Selank decreased level of anxiety of rats with toxic damage of DA neurons in elevated cross shaped maze. Previously such effects of Selank were revealed in healthy rodents (rats and mice) with different models of psycho-emotional stress. Therefore, toxic damage of substantia nigra does not affect the response of the rat organism on this peptide.
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References
Ashmarin, I.P. and Obukhova, M.F., Biokhimiya. 1986, vol. 51, no. 4, pp. 531–545.
Koroleva, S.V. and Ashmarin, I.P., Neurosci. Behav. Physiol., 2006, vol. 36, no. 2, pp. 157–162.
Romanova, G.A., Silachev, D.N., Shakova, F.M., Kvasheninnikova, Yu.N., Viktorov, I.V., Shram, S.I., and Myasoedov, N.F., Byull. Eksp. Biol. Med., 2006, vol. 142, no. 6, pp. 663–666.
Stavchansky, V.V., Yuzhakov, V.V., Botsina, A.Y., Skvortsova, V.I., Bondurko, L.N., Tsyganova, M.G., Limborska, S.A., Myasoedov, N.F., and Dergunova, L.V., J. Mol. Neurosci., 2011, vol. 45, no. 2, pp. 177–185.
Myasoedov, N.F., Skvortsova, V.I., Nasonov, E.L., Zhuravleva, E.I., Grivennikov, I.A., Arsen’eva, E.L., and Sukhanov, I.I., Zh. Nevrol. Psikhiatrii im. S.S. Korsakova, 1999, vol. 99, no. 5, pp. 15–19.
Kozlovskaya, M.M., Kozlovskii, I.I., Val’dman, E.A., and Seredenin, S.B., Neurosci. Behav. Physiol., 2003, vol. 33, no. 9, pp. 853–860.
Kozlovskii, I.I. and Danchev, N.D., Neurosci. Behav. Physiol., 2003, vol. 33, no. 7, pp. 639–643.
Uchakina, O.N., Uchakin, P.N., Myasoedov, N.F., Andreeva, L.A., Shcherbenko, V.E., Mezentseva, M.V., Gabaeva, M.V., Sokolov, O.Yu., Zozulya, A.A., and Ershov, F.I., Zh. Nevrol. Psikhiatrii im. S.S. Korsakova, 2008, vol. 108, no. 5, pp. 71–75.
Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, New York Academic, 1998.
Narkevich, V.B., Kudrin, V.S., Klodt, P.M., Pokrovskii, A.A., Kozlovskaya, M.M., Maiskii, A.I., and Raevskii, K.S., Eksp. Klin. Farmakol., 2008, vol. 71, no. 5, pp. 8–12.
Kozlovskii, I.I., Andreeva, L.A., Kozlovskaya, M.M., Nadorova, A.V., and Kolik, L.G., Eksp. Klin. Farmakol., 2012, vol. 75, no. 2, pp. 10–13.
Sarkisova, K.Y., Kulikov, M.A., Midzyanovskaya, I.S., and Folomkina, A.A., Neurosci. Behav. Physiol., 2008, vol. 38, no. 2, pp. 119–128.
Vilenskii, D.A., Levitskaya, N.G., Andreeva, L.A., Alfeeva, L.Yu., Kamenskii, A.A., and Myasoedov, N.F., Ross. Fiziol. Zh. im. I.M. Sechenova, 2007, vol. 93, no. 6, pp. 661–669.
Eremin, K.O., Kudrin, V.S., Grivennikov, I.A., Miasoedov, N.F., and Rayevsky, K.S., Dokl. Biol. Sci., vol. 394, pp. 1–3.
Eremin, K.O., Saransaari, P., Oyya, S., and Rayevsky, K.S., Eksp. Klin. Farmakol., 2004, vol. 67, no. 2, pp. 8–11.
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Published in Russian in Doklady Akademii Nauk, 2017, Vol. 474, No. 2, pp. 264–267.
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Slominsky, P.A., Shadrina, M.I., Kolomin, T.A. et al. Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism. Dokl Biol Sci 474, 106–109 (2017). https://doi.org/10.1134/S0012496617030048
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DOI: https://doi.org/10.1134/S0012496617030048