Abstract
Myelinated fibers and myelin-forming cells in the spinal cord at the L3–L5 level were studied in C57BL/6N mice that had spent 30 days in space. Signs of destruction of myelin in different areas of white matter, reduction of the thickness of myelin sheath and axon diameter, decreased number of myelin-forming cells were detected in “flight” mice. The stay of mice in space during 30 days had a negative impact on the structure of myelinated fibers and caused reduced expression of the markers myelin-forming cells. These findings can complement the pathogenetic picture of the development of hypogravity motor syndrome.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Grigor’ev, A.I., Kozlovskaya, I.B., and Shenkman, B.S., Ross. Fiziol. Zh. im. I.M. Sechenova, 2004, no. 5, p. 508–521.
Morey-Holton, E.R. and Globus, R.K., J. Appl. Physiol., 2002, vol. 92, pp. 1367–1377.
Chelyshev, Y.A., Muhamedshina, Y.O., and Povysheva, T.V., Neuroscience, 2014, vol. 280, pp. 328–339.
Tyapkina, O.V., Rezvyakov, P.N., Nurullin, L.F., et al., Geny Kletki, 2014, vol. 9, no. 3, pp. 263–266.
Snipes, G.J. and Suter, U., J. Anat., 1995, vol. 186, pp. 483–494.
Marchesi, C., Milani, M., Morbin, M., et al., Neurology, 2010, vol. 75, pp. 1830–1838.
Ren, J.C., Fan, X.L., Song, X.A., et al., Muscle Nerve, 2012, vol. 45, no. 1, pp. 65–69.
Andreev-Andrievskii, A.A., Shenkman, B.S., Popova, A.S., et al., Aviakosm. Ekol. Med., 2014, vol. 48, no. 1, pp. 14–27.
Bisler, S., Schleicher, A., Gass, P., et al., J. Chem. Neuroanat., 2002, pp. 187–198.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © T.V. Povysheva, P.N. Rezvyakov, G.F. Shaimardanova, E.E. Nikolskii, R.R. Islamov, Yu.A. Chelyshev, A.I. Grygoryev, 2016, published in Doklady Akademii Nauk, 2016, Vol. 469, No. 6, pp. 756–759.
Rights and permissions
About this article
Cite this article
Povysheva, T.V., Rezvyakov, P.N., Shaimardanova, G.F. et al. Myelinated fibers of the mouse spinal cord after a 30-day space flight. Dokl Biol Sci 469, 163–166 (2016). https://doi.org/10.1134/S0012496616040153
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0012496616040153