Skip to main content
SpringerLink
Log in

Biological activity of a polypeptide modulator of TRPV1 receptor

  • General Biology
  • Published:
Doklady Biological Sciences Aims and scope Submit manuscript

Abstract

This paper presents data on the activity of a new APHC2 polypeptide modulator of TRPV1 receptors, which was isolated from the sea anemone Heteractis crispa. It has been shown that APHC2 has an analgesic activity, does not impair normal motor activity, and does not change body temperature of experimental animals, which has a great practical value for design of potent analgesics of a new generation. Further study of the characteristics of binding of the polypeptide to the TRPV1 receptor may show approaches to the development of other antagonists of this receptor that do not influence the body temperature.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Szallasi, A., Cortright, D.N., Blum, C.A., and Eid, S.R., Nat. Rev. Drug. Discov., 2007, vol. 6, no. 5, pp. 357–372.

    Article  PubMed  CAS  Google Scholar 

  2. Andreev, Y.A., Vassilevski, A.A., and Kozlov, S.A., Recent Pat. Inflamm. Allergy Drug Discov., 2012, vol. 6, no. 1, pp. 35–45.

    Article  PubMed  CAS  Google Scholar 

  3. Andreev, Y.A., Kozlov, S.A., Koshelev, S.G., et al., J. Biol. Chem., 2008, vol. 283, no. 35, pp. 23914–23921.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  4. Andreev, Ya.A., Kozlov, S.A., Kozlovskaya, E.P., and Grishin, E.V., Dokl. Biochem. Biophys., 2009, vol. 424, no. 5, pp. 46–48.

    Article  PubMed  CAS  Google Scholar 

  5. Kozlov, S.A., Andreev, Y.A., Murashev, A.N., et al., Rus. J. Bioorg. Chem., 2009, vol. 35, no. 6, pp. 711–719.

    Article  CAS  Google Scholar 

  6. Philyppov, I.B., Paduraru, O.N., Andreev, Y.A., et al., Life Sci., 2012, vol. 91, no. 19/20, pp. 912–920.

    Article  PubMed  CAS  Google Scholar 

  7. Andreev, Y.A., Kozlov, S.A., Korolkova, Y.V., et al., Mar. Drugs, 2013, vol. 11, no. 12, pp. 5100–5115.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  8. Andreev, Y.A., Kozlov, S.A., Vassilevski, A.A., and Grishin, E.V., Anal. Biochem., 2010, vol. 407, no. 1, pp. 144–146.

    Article  PubMed  CAS  Google Scholar 

  9. Caterina, M.J., Leffler, A., Malmberg, A.B., et al., Science, 2000, vol. 288, no. 5464, pp. 306–313.

    Article  PubMed  CAS  Google Scholar 

  10. Gavva, N.R., Tamir, R., Qu, Y., Klionsky, L., et al., J. Pharmacol. Exp. Ther., 2005, vol. 313, no. 1, pp. 474–484.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pushchino Branch, Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow oblast, 142292, Russia

    I. A. Dyachenko & A. N. Murashev

  2. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117871, Russia

    Ya. A. Andreev, Yu. A. Logashina & E. V. Grishin

Authors
  1. I. A. Dyachenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ya. A. Andreev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yu. A. Logashina
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. N. Murashev
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. V. Grishin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I. A. Dyachenko.

Additional information

Original Russian Text © I.A. Dyachenko, Ya.A. Andreev, Yu.A. Logashina, A.N. Murashev, E.V. Grishin, 2015, published in Doklady Akademii Nauk, 2015, Vol. 465, No. 2, pp. 252–254.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dyachenko, I.A., Andreev, Y.A., Logashina, Y.A. et al. Biological activity of a polypeptide modulator of TRPV1 receptor. Dokl Biol Sci 465, 279–281 (2015). https://doi.org/10.1134/S0012496615060034

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0012496615060034

Keywords

Search

Navigation