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Role of B cells in presentation of autoantigens to CD4+ T cells in patients with autoimmune thyroiditis

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Abstract

The antigen-presenting activity of B cells and expression of molecules involved in antigen presentation by B cells have been studied in patients with autoimmune thyroiditis (AIT). The disease is characterized by enhanced expression of the costimulatory molecule CD80 in naive B cells (CD19+CD27− cells) both ex vivo and under the conditions of polyclonal cell activation in a culture. Under in vitro conditions, antigen-loaded B cells have been shown to be capable of inducing proliferation of autologous CD4+ cells, in particular, proliferation of autospecific T cells in patients with AIT. Given that an intense infiltration of thyroid tissue by B cells is a typical sign of AIT, the antigen-presenting activity of B cells appears to contribute to this pathology.

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Authors and Affiliations

  1. Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm’, Russia

    E. M. Kuklina & I. V. Nekrasova

  2. Perm’ State Medical University, Perm’, Russia

    E. N. Smirnova & T. S. Balashova

Authors
  1. E. M. Kuklina
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  2. E. N. Smirnova
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  3. I. V. Nekrasova
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  4. T. S. Balashova
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Correspondence to E. M. Kuklina.

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Original Russian Text © E.M. Kuklina, E.N. Smirnova, I.V. Nekrasova, T.S. Balashova, 2015, published in Doklady Akademii Nauk, 2015, Vol. 464, No. 4, pp. 508–511.

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Kuklina, E.M., Smirnova, E.N., Nekrasova, I.V. et al. Role of B cells in presentation of autoantigens to CD4+ T cells in patients with autoimmune thyroiditis. Dokl Biol Sci 464, 263–266 (2015). https://doi.org/10.1134/S0012496615050099

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  • DOI: https://doi.org/10.1134/S0012496615050099

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