Abstract
The role of casein kinase 2 (CK2) in the activation of the key NF-κB signaling cascade and other signaling and stress proteins during stress induced by exposure to nonthermal low-intensity electromagnetic radiation has been investigated. The ability of CK2 to regulate the activation of the NF-κB signaling cascade and upregulate the proinflammatory cytokine production and TLR4 receptor expression has been demonstrated. The existence of an alternative signaling pathway for NF-κB cascade activation directly involving protein kinase CK2 has been demonstrated using inhibition analysis in cells stressed by microwave irradiation.
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Original Russian Text © O.V. Glushkova, M.O. Khrenov, T.V. Novoselova, S.M. Lunin, E.E. Fesenko, E.G. Novoselova, 2015, published in Doklady Akademii Nauk, 2015, Vol. 464, No. 4, pp. 505–507.
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Glushkova, O.V., Khrenov, M.O., Novoselova, T.V. et al. The role of CK2 protein kinase in stress response of RAW 264.7 macrophages. Dokl Biol Sci 464, 260–262 (2015). https://doi.org/10.1134/S0012496615050087
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DOI: https://doi.org/10.1134/S0012496615050087