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Piezo Pulsometric Analysis of the Functional State of the Human Cardiovascular System

  • MEDICAL BIOPHYSICS
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Abstract

The article expounds, with examples, how to apply the computer method of arterial piezo pulsometry designed to provide a rapid noninvasive test for the functional state and the nature of autonomic regulation of the cardiovascular (CV) system in patients varying in age and health status. The involvement and role were assessed for the contractile component of left ventricular (LV) myocytes as a universal muscle effector that ensures both the basic pumping function of the heart and the implementation of the autonomic regulation of heart contractions via peripheral neurohumoral mechanisms that maintain the optimal level of cardiac hemodynamics. The analysis was found to enhance the predictive value of early noninvasive pulsometric diagnosis of the individual functional state and the nature of the regulation of the human CV system during ontogeny. This knowledge helps identifying the risk that may threaten the evolutionary ability of the CV system to maintain a dynamic balance, self-regulation, and adaptation to changing environmental conditions and is associated with distorted homeostasis of the body.

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REFERENCES

  1. Methods for Studying the Cardiovascular System, Guide to Cardiology, Ed. by E. I. Chazov, (Moscow, 1982), Vol. 2 [in Russian].

    Google Scholar 

  2. N. Ferrara, K. Komici, G. Corbi, et al., Front. Physiol. 4, 396 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  3. I. V. Shemarova, V. P. Nesterov, L. V. Emelyanova, et al., Front. Biosci., Scholar Ed. 13, 105 (2021).

  4. G. F. Mitchell, H. Parise, E. J. Benjamin, et al., Hypertension 43, 1239 (2004).

    Article  CAS  PubMed  Google Scholar 

  5. A. Schumann and K. Bar, PhysioNet (2021). https://doi.org/10.13026/2hsy-t491

  6. N. R. Paleev and I. M. Kaevitser, Atlas of Hemodynamic Studies in the Clinic of Internal Diseases (Meditsina, Moscow, 1975).

    Google Scholar 

  7. S. V. Nesterov, Hum. Physiol. 31 (1), 70 (2005).

    Article  Google Scholar 

  8. V. P. Nesterov, A. I. Burdygin, and S. V. Nesterov, Hum. Physiol. 43, 653 (2017).

  9. V. P. Nesterov, A. I. Burdygin, K. B. Ivanov, et al., Zh. Evol. Biokhim. Fiziol. 31 (6), 433 (2019).

    Article  Google Scholar 

  10. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use, Eur. Heart J. 17 (3), 354 (1995).

  11. J. A. Taylor and D. L. Eckberg, Circulation 93 (8), 1527 (1996).

    Article  CAS  PubMed  Google Scholar 

  12. W. N. Wilmer, J. D. Scott, I. B. Wilkinson, et al., J. Clin. Hypertens. 10, 295 (2008).

    Article  Google Scholar 

  13. V. P. Nesterov, M. F. Ballyuzek, A. O. Konradi, et al., Usp. Gerontol. 29, 107 (2016).

    CAS  Google Scholar 

  14. S. A. Kotel’nikov, A. D. Nozdrachev, M. M. Odinak, et al., Hum. Physiol. 28, 114 (2002).

  15. J. H. Skotte and J. Kristiansen, Biomed. Eng. Online 13, 138 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  16. V. P. Nesterov, A. I. Burdygin, K. B. Ivanov, et al., Adv. Gerontol. 12, 147 (2022).

    Article  Google Scholar 

  17. V. P. Nesterov, A. I. Burdygin, K. B. Ivanov, et al., Biophysics 68, 21 (2023).

    Article  Google Scholar 

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ACKNOWLEDGMENTS

We are grateful to our colleagues for generous help in collecting the pulsometric data.

Funding

This work was supported by state contract no. 075-00967-23-00. No additional grants to carry out or direct this particular research were obtained.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223, St. Petersburg, Russia

    V. P. Nesterov, A. I. Burdygin, K. B. Ivanov, K. V. Sobol & I. V. Shemarova

Authors
  1. V. P. Nesterov
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  2. A. I. Burdygin
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  3. K. B. Ivanov
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  4. K. V. Sobol
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  5. I. V. Shemarova
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Corresponding author

Correspondence to V. P. Nesterov.

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CONFLICT OF INTEREST

The authors of this work declare that they have no conflicts of interest.

ETHICS APPROVAL AND CONSENT TO PARTICIPATE

All procedures performed in studies involving human participants were not associated with any risk to the subjects and were conducted in accordance with the principles of biomedical ethics as outlined in the 1964 Declaration of Helsinki and its later amendments. Each participant in the study provided a voluntary written informed consent after receiving an explanation of the potential risks and benefits,as well as the nature of the upcoming study. The method was clinically tested at the Almazov National Medical Research Center (Ministry of Health of the Russian Federation, protocol of November 2, 2013.) and St. Petersburg Clinical Hospital (the Russian Academy of Sciences, protocol of April 11, 2013.) and found to exert no adverse effect in humans.

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Translated by T. Tkacheva

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Abbreviations: CV, cardiovascular; DPP, differential piezo pulsometry; PP, pulse pressure; LV, left ventricle; ME, muscle effector; VNS, vegetative nervous system; Vpp, pulse pressure change rate; TNN, cardiac cycle duration; PPn, normalized pulse pressure; VmaxPP, maximum pulse pressure increase rate; AIx%, augmentation index; RW, reflected wave.

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Nesterov, V.P., Burdygin, A.I., Ivanov, K.B. et al. Piezo Pulsometric Analysis of the Functional State of the Human Cardiovascular System. BIOPHYSICS 68, 1066–1075 (2023). https://doi.org/10.1134/S0006350923060131

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