Abstract
This work concerns the mechanism of the action of gold polyacrylate (aurumacryl) on human blood lymphocytes. The effects of the medication on cell viability and DNA structure and the ability to induce reactive oxygen species are studied. It has been found that aurumacryl exhibits a dose- and exposure-dependent cytotoxic activity, causes single-stranded DNA breaks, and induces the generation of intracellular reactive oxygen species.
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Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.
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Translated by V. Gulevich
Abbreviation: ROS, reactive oxygen species.
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Chigasova, A.K., Ostrovskaya, L.A. & Korman, D.B. Mechanism of the Cytotoxic Action of Gold Polyacrylate on Human Blood Lymphocytes. BIOPHYSICS 67, 968–971 (2022). https://doi.org/10.1134/S0006350922060057
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DOI: https://doi.org/10.1134/S0006350922060057