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1H NMR Study of the Effect of tert-Butyl Alcohol on Collagen I

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Abstract

The effect of tert-butyl alcohol ((CH3)3COH) on the dynamic states of collagen I macromolecules in the bovine Achilles tendon has been studied for the first time using 1H NMR spectroscopy. It appears that exposure (CH3)3COH can cause changes in the mobility of the CH2 groups in the macromolecules due to interactions between the aqueous subsystem and collagen macromolecules. The interactions are most strongly manifested during the phase transition in the (CH3)3COH/H2O system.

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ACKNOWLEDGMENTS

The authors thank Professor S. P. Gabuda for the problem statement of studying interactions in biological connective tissues.

Funding

The work was supported by the Ministry of Science and Higher Education of the Russian Federation (State Task no. 121031700313-8).

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Authors and Affiliations

  1. Moscow Aviation Institute (National Research University), 125993, Moscow, Russia

    M. N. Mashkin

  2. Moscow State University of Food Production, 125080, Moscow, Russia

    V. A. Mashkina

  3. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090, Novosibirsk, Russia

    S. G. Kozlova

  4. Shukhov Belgorod State Technological University, 308012, Belgorod, Russia

    S. G. Kozlova

Authors
  1. M. N. Mashkin
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  2. V. A. Mashkina
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  3. S. G. Kozlova
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Corresponding author

Correspondence to S. G. Kozlova.

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CONFLICT OF INTEREST

The authors declare that they have no conflicts of interest.

COMPLIANCE WITH ETHICAL STANDARDS

This article does not contain any studies with the use of humans and animals as objects of research.

Additional information

Translated by A. Levina

Abbreviations: BAT, bovine Achilles tendon.

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Mashkin, M.N., Mashkina, V.A. & Kozlova, S.G. 1H NMR Study of the Effect of tert-Butyl Alcohol on Collagen I. BIOPHYSICS 67, 884–887 (2022). https://doi.org/10.1134/S0006350922050116

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  • DOI: https://doi.org/10.1134/S0006350922050116

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