Abstract
A role for presynaptic signaling was found in the processes of adaptation to allergies during isometric contractions of mouse EDL (fast) and soleus (slow) muscles evoked by electrical stimulation and mechanomyography. Differences in the dynamics of the functional characteristics of muscles under the influence of exogenous ATP in intact and egg albumin-sensitized animals demonstrate that purinergic mechanisms are involved more in the development of adaptive changes in the presynaptic side of “fast” muscles than in “slow” muscles. In the process of protein sensitization, complex ATP-dependent mechanisms of the postsynaptic membrane and the presynaptic membrane ensure adequate reorganization of the contractile function of locomotor muscles in case of allergy and these mechanisms differ significantly in different muscles.
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Funding
The work was carried out within the program “Strategic Academic Leadership” (PRIORITET-2030) of Kazan Federal University, as well as at the expense of a subsidy allocated to Kazan State Medical University of the Ministry of Health of Russia for scientific research within the University Development Program.
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Statement on the welfare of animals. All manipulations with experimental animals were carried out in accordance with the European Convention for the Protection of Vertebrate Animals used in scientific research.
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Translated by P. Kuchina
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Khairullin, A.E., Teplov, A.Y., Grishin, S.N. et al. Purinergic Mechanisms of Adaptation of Different Types of Motor Units under Conditions of Allergic Reorganization. BIOPHYSICS 67, 996–999 (2022). https://doi.org/10.1134/S0006350922050098
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DOI: https://doi.org/10.1134/S0006350922050098