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The Ratio of Cation Selectivity of Channels Formed by Peroxiredoxin 6 in Bimolecular Phospholipid Membranes

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Abstract

Peroxiredoxin 6 is an enzyme that protects against cellular damage caused by peroxides and participates in phospholipid metabolism in cell membranes depending on its location. It has also been shown that peroxiredoxin 6 forms cation channels in lipid bilayer membranes. In this study, the relative selectivity of these channels for monovalent and divalent cations was evaluated. The ratio of cation selectivity was found to be \({{P}_{{{\text{C}}{{{\text{a}}}^{{2 + }}}}}}{\kern 1pt} :{{P}_{{\text{K}}}} + {{P}_{{{\text{N}}{{{\text{a}}}^{ + }}}}}\) = 8.5 : 5.0 : 1.0.

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Authors and Affiliations

  1. Institute of Cell Biophysics, Russian Academy of Sciences, 142290, Pushchino, Moscow oblast, Russia

    P. A. Grigoriev

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  1. P. A. Grigoriev
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Correspondence to P. A. Grigoriev.

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Conflict of interest. The author declares that he has no conflicts of interest.

Statement on the welfare of humans or animals. This article does not contain any studies involving animals performed by the author.

Additional information

Translated by E. Puchkov

Abbreviations: cAMP, Prx6, peroxiredoxin 6.

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Grigoriev, P.A. The Ratio of Cation Selectivity of Channels Formed by Peroxiredoxin 6 in Bimolecular Phospholipid Membranes. BIOPHYSICS 67, 200–202 (2022). https://doi.org/10.1134/S0006350922020075

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  • DOI: https://doi.org/10.1134/S0006350922020075

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