The Change of Electrical Properties of Blood Corpuscles under in vitro Mechanical Stress

Abstract

Changes in the electrical properties of blood corpuscles that are experiencing mechanical stress modeled in vitro have been studied. An increase in the concentration of ATP molecules in the intercellular space in response to the mechanical effect of moving plasma layers both in the blood of healthy people and patients with acute lymphoblastic leukemia is demonstrated. The surface potential of red blood cells and platelets becomes more positive both in the blood of healthy people and in leukemia patients. In contrast, the negative charge of lymphocytes in healthy people decreases in response to mechanical stress but increases in the blood of patients with acute lymphoblastic leukemia.

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Funding

This work was supported by the Russian Science Foundation, Studies Initiated by Young Scientists project, 2018–2020, progect no. 18-75-00041.

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Correspondence to E. A. Sladkova.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of animals: All manipulations with humans met the ethical standards of the Declaration of Helsinki, 1964, with later amendments. Informed consent was obtained from each participant of the study.

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Translated by V. Gulevich

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Sladkova, E.A. The Change of Electrical Properties of Blood Corpuscles under in vitro Mechanical Stress. BIOPHYSICS 65, 775–778 (2020). https://doi.org/10.1134/S000635092005019X

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  • Keywords: mechanical stress
  • purinergic signaling system
  • surface potential
  • lymphocytes
  • red blood cells
  • platelets