The Sigma-1 Receptor Ligands Chlorpromazine and Trifluoperazine Inhibit Na+ Transport in Frog Skin Epithelium

Abstract

Using the voltage-clamp technique, it has been shown for the first time that the neuroleptic drugs chlorpromazine and trifluoperazine, which act as sigma-1 receptor antagonists, attenuate Na+ transport in the frog skin epithelium. The results suggest that sigma-1 receptors may be involved in the regulation of transepithelial Na+ transport in frog skin.

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Funding

This study was conducted as a part of the research program of the Department of Biophysics of St. Petersburg State University and the Department of Clinical Bioche-mistry and Laboratory Diagnostics of the Kirov Military Medical Academy (St. Petersburg) and was supported by Research and Development Agreement no. 28-12-38.

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Correspondence to A. V. Melnitskaya or Z. I. Krutetskaya.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. All applicable international, national, and institutional guidelines for the care and use of animals were followed.

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Translated by D. Timchenko

Abbreviations: ENaC—amiloride-sensitive epithelial sodium channel; Deg/ENaC—degenerin/epithelial sodium channel superfamily; ASICs—acid-sensing ion channels; CP—chlorpromazine; TFP—trifluoperazine.

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Melnitskaya, A.V., Krutetskaya, Z.I., Antonov, V.G. et al. The Sigma-1 Receptor Ligands Chlorpromazine and Trifluoperazine Inhibit Na+ Transport in Frog Skin Epithelium. BIOPHYSICS 65, 784–787 (2020). https://doi.org/10.1134/S0006350920050115

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  • Keywords: sigma-1 receptors
  • Na+ transport
  • chlorpromazine
  • trifluoperazine