Abstract
Using the voltage-clamp technique, it has been shown for the first time that the neuroleptic drugs chlorpromazine and trifluoperazine, which act as sigma-1 receptor antagonists, attenuate Na+ transport in the frog skin epithelium. The results suggest that sigma-1 receptors may be involved in the regulation of transepithelial Na+ transport in frog skin.
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REFERENCES
Yu. V. Natochin, Fundamentals of Renal Physiology (Nauka, Leningrad, 1982) [in Russian].
S. Kellenberger and L. Schild, Physiol. Rev. 82, 735 (2002).
C. G. Rousseaux and S. F. Greene, J. Recept. Signal. Trans. 36, 327 (2016).
S. B. Hellewell, A. Bruce, G. Feinstein, et al., Eur. J. Pharmacol. 268, 9 (1994).
E. J. Cobos, J. M. Entrena, F. R. Nieto, et al., Curr. Neuropharmacol. 6, 344 (2008).
Y. Itzhak, M. Ruhland, and H. Krahling, Neuropharmacology 29, 181 (1990).
B. Penke, L. Fulop, M. Szucs, et al., Curr. Neuropharmacol. 16, 97 (2018).
T.-P. Su, T. Hayashi, T. Maurice, et al., Trends Pharmacol. Sci. 31, 557 (2010).
S. M. Carnally, M. Johannessen, R. M. Henderson, et al., Biophys. J. 98, 1182 (2010).
Z. I. Krutetskaya, O. E. Lebedev, A. V. Melnitskaya, et al., Dokl. Akad. Nauk 421 (5), 709 (2008).
R. W. Van Dyke and B. F. Scharschmidt, Am. J. Physio-l. 253, 613 (1987).
P. Else and K. Mansfield, Biochem. Pharmacol. 54, 275 (1997).
M. S. Awayda, W. Shao, F. Guo, et al., J. Gen. Physiol. 123, 709 (2004).
S. D. Levine, W. A. Kachadorian, D. N. Levin, et al., J. Clin. Invest. 67 (3), 662 (1981).
H. F. Bjerregaard and R. Nielsen, Acta Physiol. Scand. 127 (1), 75 (1986).
H. F. Bjerregaard and R. Nielsen, Acta Physiol. Scand. 134 (1), 43 (1988).
M. D. Feldkamp, S. E. O’Donnell, L. Yu, et al., Proteins 78 (10), 2265 (2010).
Y. Herrera, C. Katnik, J. D. Rodriguez, et al., J. Pharmacol. Exp. Ther. 327, 491 (2008).
A. V. Melnitskaya, Z. I. Krutetskaya, S. N. Butov, et al., in Receptors and Intracellular Signaling, Ed. by V. P. Zin-chenko and A. V. Berezhnov (Fix-Print, Pushchino, 2017), pp. 55–58.
Funding
This study was conducted as a part of the research program of the Department of Biophysics of St. Petersburg State University and the Department of Clinical Bioche-mistry and Laboratory Diagnostics of the Kirov Military Medical Academy (St. Petersburg) and was supported by Research and Development Agreement no. 28-12-38.
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Translated by D. Timchenko
Abbreviations: ENaC—amiloride-sensitive epithelial sodium channel; Deg/ENaC—degenerin/epithelial sodium channel superfamily; ASICs—acid-sensing ion channels; CP—chlorpromazine; TFP—trifluoperazine.
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Melnitskaya, A.V., Krutetskaya, Z.I., Antonov, V.G. et al. The Sigma-1 Receptor Ligands Chlorpromazine and Trifluoperazine Inhibit Na+ Transport in Frog Skin Epithelium. BIOPHYSICS 65, 784–787 (2020). https://doi.org/10.1134/S0006350920050115
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DOI: https://doi.org/10.1134/S0006350920050115