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Ultrasonic DNA Cleavage: An Analysis of the Conformational-Dynamic Features of Regulatory Genome Regions and Sequencing Errors

  • MOLECULAR BIOPHYSICS
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Abstract

This review is dedicated to the memory of Dr. Sergei L’vovich Grokhovsky, who was a distinguished scientists and experimenter; it briefly describes one aspect of his multifaceted research activity. Gro-khovsky was the first to describe the specificity of ultrasound-induced cleavage of internucleotide bonds in double-stranded B-DNA. The discovery of this new physicochemical phenomenon made it possible to associate the cleavage effects with conformational and dynamic features of B-DNA nucleotide sequences and provided a new basis for bioinformatics genome analyses. Certain conformational dynamic specifics are characteristic of functional DNA regions; this makes it possible to formulate and solve a number of problems of epigenetics and carcinogenesis.

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ACKNOWLEDGMENTS

We are grateful to D.Yu. Nechipurenko and L.A. Uroshlev for helpful discussion.

Funding

This work was supported by the Program of Basic Research for State Academies of Sciences for the Period from 2013 to 2020 (project nos. 01201363818 and 01201363820), the Program for Molecular and Cell Biology of the Presidium of the Russian Academy of Sciences (project no. 01201456592), and the Russian Foundation for Basic Research (project no. 18-07-00354a).

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Authors and Affiliations

  1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russia

    I. A. Il’icheva, M. V. Khodikov & Yu. D. Nechipurenko

  2. Department of Biology, Moscow State University, 119991, Moscow, Russia

    L. A. Panchenko

  3. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290, Pushchino, Moscow oblast, Russia

    R. V. Polozov

Authors
  1. I. A. Il’icheva
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  2. M. V. Khodikov
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  3. L. A. Panchenko
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  4. R. V. Polozov
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  5. Yu. D. Nechipurenko
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Corresponding authors

Correspondence to I. A. Il’icheva or Yu. D. Nechipurenko.

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Conflict of interests. The authors declare that they have no conflict of interest.

This review does not contain any studies involving animals or human subjects performed by any of the authors.

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Translated by T. Tkacheva

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Il’icheva, I.A., Khodikov, M.V., Panchenko, L.A. et al. Ultrasonic DNA Cleavage: An Analysis of the Conformational-Dynamic Features of Regulatory Genome Regions and Sequencing Errors. BIOPHYSICS 65, 426–432 (2020). https://doi.org/10.1134/S0006350920030082

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  • DOI: https://doi.org/10.1134/S0006350920030082

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