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The Antitumor Activity of Dinitrosyl Iron Complexes with Mercaptosuccinate in Murine Solid Tumor Models

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Abstract

The antitumor activity of the binuclear form of dinitrosyl iron complexes with mercaptosuccinate administered intravenously was studied in murine models of solid tumors: Lewis lung carcinoma and Acatol adenocarcinoma. The maximum effect, suppression of tumor growth by 65% in comparison to the control for Lewis carcinoma, was observed for a course of six intravenous injections in a daily dose of 2.5 μM/kg administered every 2 or 3 days over the period of days 1–17 after tumor transplantation.

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Authors and Affiliations

  1. Semenov Institute of Chemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia

    A. F. Vanin

  2. Institute of Regenerative Medicine, Sechenov First Moscow State Medical University, 119991, Moscow, Russia

    A. F. Vanin

  3. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia

    L. A. Ostrovskaya, D. B. Korman, N. V. Bluchterova, V. A. Rykova & M. M. Fomina

Authors
  1. A. F. Vanin
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  2. L. A. Ostrovskaya
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  3. D. B. Korman
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  4. N. V. Bluchterova
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  5. V. A. Rykova
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  6. M. M. Fomina
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Corresponding author

Correspondence to A. F. Vanin.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

Additional information

Translated by D. Timchenko

Abbreviations used: B-DNIC-G, binuclear dinitrosyl iron complexes with glutathione; B-DNIC-S, binuclear dinitrosyl iron complexes with mercaptosuccinate; TGI, tumor growth inhibition coefficient.

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Vanin, A.F., Ostrovskaya, L.A., Korman, D.B. et al. The Antitumor Activity of Dinitrosyl Iron Complexes with Mercaptosuccinate in Murine Solid Tumor Models. BIOPHYSICS 64, 999–1002 (2019). https://doi.org/10.1134/S0006350919060228

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  • DOI: https://doi.org/10.1134/S0006350919060228

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