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The Cytotoxicity of Cold Atmospheric Plasma against HeLa Cancer Cells and its Modification with Pharmaceutical Substances

  • CELL BIOPHYSICS
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Abstract

It has been shown that low-temperature non-equilibrium piezoelectric direct discharge plasma exerts a dose-dependent cytotoxic effect on a HeLa cell culture. Doxorubicin, an antitumor antibiotic, potentiates this effect of cold plasma, while dihydroquercetin, as an antioxidant, attenuates it.

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Funding

This work was supported by the Russian Foundation for Basic Research, project no. 9-02-00378a.

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Authors and Affiliations

  1. Pirogov Russian National Research Medical University, 117997, Moscow, Russia

    A. G. Akopdzhanov, N. L. Shimanovskii, D. S. Stepanova, T. A. Fedotcheva, A. V. Pulish, N. G. Gusein-zade, L. V. Kolik & E. M. Konchekov

  2. Prokhorov General Physics Institute, Russian Academy of Sciences, 119991, Moscow, Russia

    N. G. Gusein-zade, L. V. Kolik & E. M. Konchekov

Authors
  1. A. G. Akopdzhanov
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  2. N. L. Shimanovskii
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  3. D. S. Stepanova
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  4. T. A. Fedotcheva
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  5. A. V. Pulish
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  6. N. G. Gusein-zade
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  7. L. V. Kolik
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  8. E. M. Konchekov
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Corresponding author

Correspondence to A. G. Akopdzhanov.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. This article does not contain any studies involving animals performed by any of the authors.

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Translated by Victor Gulevich

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Akopdzhanov, A.G., Shimanovskii, N.L., Stepanova, D.S. et al. The Cytotoxicity of Cold Atmospheric Plasma against HeLa Cancer Cells and its Modification with Pharmaceutical Substances. BIOPHYSICS 64, 926–929 (2019). https://doi.org/10.1134/S0006350919060034

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  • DOI: https://doi.org/10.1134/S0006350919060034

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