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A Precision Approach to the Diagnosis and Choice of Tactics in the Treatment of Endometrial Hyperplasia in Perimenopause

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Abstract—This study was aimed at the identification of the most significant clinical, anatomical, and molecular risk factors of the occurrence and progression of endometrial hyperplastic processes and the development of endometrial malignant transformation in women of perimenopause age taking statistical analysis into account. The results enabled us to find statistically significant risk factors for endometrial cancer. The degree of cancer risk was calculated using the method of binary logistic regression; the effective tactics of management of patients with endometrial hyperplastic processes in perimenopause was chosen.

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Authors and Affiliations

  1. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, 119991, Moscow, Russia

    E. A. Kogan, A. L. Unanyan & D. V. Baburin

  2. Institute of Nuclear Physics, Moscow State University, 119991, Moscow, Russia

    V. A. Namiot

  3. Institute of Physicochemical and Biological Problems in Soil Science, Russian Academy of Sciences, 142290, Pushchino, Moscow oblast, Russia

    S. N. Udaltsov

Authors
  1. E. A. Kogan
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  2. A. L. Unanyan
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  3. V. A. Namiot
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  4. D. V. Baburin
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  5. S. N. Udaltsov
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Corresponding author

Correspondence to V. A. Namiot.

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Conflict of Interest. The authors state that there is no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. All procedures performed in the human study are in accordance with the ethical standards of the institutional and/or national research ethics Committee and the 1964 Helsinki Declaration and its subsequent changes or comparable ethical standards. Informed voluntary consent was obtained from each of the participants included in the study.

Additional information

Translated by E. Puchkov

Abbreviations: EHP, endometrial hyperplastic processes; CSC, cancer stem cells; RR, the relative risk factor of endometrial cancer.

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Kogan, E.A., Unanyan, A.L., Namiot, V.A. et al. A Precision Approach to the Diagnosis and Choice of Tactics in the Treatment of Endometrial Hyperplasia in Perimenopause. BIOPHYSICS 64, 649–656 (2019). https://doi.org/10.1134/S0006350919040055

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  • DOI: https://doi.org/10.1134/S0006350919040055

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