Abstract—The objective of this work was to study the biological effect of dinitrosyl iron complexes (DNICs) with the glutathione ligand (GSH−DNICs) as a stabilized form of nitric oxide in a rat model of nitric oxide hyperproduction induced by inflammation. Administration of GSH−DNICs in endotoxin shock did not increase the total nitric oxide levels in rat organs, but exerted a protective effect by suppressing nitric oxide hyperproduction in the liver and led to an accumulation of the complexes with protein ligands in the kidney.
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This work was supported by the Russian Foundation for Basic Research (project no. 18-015-00027).
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Abbreviations: DNIC, dinitrosyl iron complex; GSH−DNICs, dinitrosyl iron complex with glutathione as a ligand; LPS, lipopolysaccharide; AST, aspartate aminotransferase; EPR, electron paramagnetic resonance.
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Timoshin, A.A., Lakomkin, V.L., Abramov, A.A. et al. The Biological Effect of Dinitrosyl Iron Complexes with Glutathione upon Nitric Oxide Hyperproduction Induced by Endotoxin Shock. BIOPHYSICS 64, 89–94 (2019). https://doi.org/10.1134/S0006350919010196
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DOI: https://doi.org/10.1134/S0006350919010196