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An Experimental Study of the Pharmacokinetics of the Antitumor Drug Aurumacryl

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Abstract

The distribution of the antitumor drug aurumacryl (intraperitoneally injected at a dose of 100 mg/kg) in the bodies of animals with Lewis lung carcinoma was studied. The determination of aurumacryl in the tumors and organs (blood, liver, kidneys, lungs, spleen, and brain) of mice was carried out for 48 h by measuring the gold content in the test tissues using inductively coupled plasma mass spectrometry. We found the preferential accumulation of the drug in the kidneys with an extremely low gold content in the brain and a relatively uniform distribution of aurumacryl between the tumor, liver, lung, and spleen tissues.

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Abbreviations

ICP-MS:

inductively coupled plasma mass spectrometry

RB:

relative bioavailability

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Authors and Affiliations

  1. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 119334, Russia

    L. A. Ostrovskaya, D. B. Korman, V. A. Kuzmin, N. V. Bluhterova, M. M. Fomina, V. A. Rikova & R. R. Guliev

  2. Institute of Microelectronic Technology and Ultra-High-Purity Materials, Russian Academy of Sciences, ul. Akademika Osipyana 6, Chernogolovka, 142432, Russia

    J. P. Burmiy

  3. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, ul. Favorskogo 1, Irkutsk, 664033, Russia

    K. A. Abzaeva

Authors
  1. L. A. Ostrovskaya
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  2. D. B. Korman
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  3. J. P. Burmiy
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  4. V. A. Kuzmin
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  5. N. V. Bluhterova
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  6. M. M. Fomina
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  7. V. A. Rikova
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  8. R. R. Guliev
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  9. K. A. Abzaeva
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Corresponding author

Correspondence to L. A. Ostrovskaya.

Additional information

Original Russian Text © L.A. Ostrovskaya, D.B. Korman, J.P. Burmiy, V.A. Kuzmin, N.V. Bluhterova, M.M. Fomina, V.A. Rikova, R.R. Guliev, K.A. Abzaeva, 2018, published in Biofizika, 2018, Vol. 63, No. 3, pp. 606–614.

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Ostrovskaya, L.A., Korman, D.B., Burmiy, J.P. et al. An Experimental Study of the Pharmacokinetics of the Antitumor Drug Aurumacryl. BIOPHYSICS 63, 469–476 (2018). https://doi.org/10.1134/S0006350918030181

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  • DOI: https://doi.org/10.1134/S0006350918030181

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