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Use of Ultrasound for Creation of Highly Targeted Immune Response

  • Molecular Biophysics
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Abstract

A simple method for creating a highly targeted immune response has been proposed. It has been shown that under the impact of low- and moderate-intensity ultrasound it is possible to strip antigens off the cell surface (surface antigens). It has been found that the immunogenicity of these surface antigens is no lower than the immunogenicity of intact cells. These results imply that it may be possible to create a specific highly targeted immune response against tissues and cells from whose surface the antigens were stripped, in particular, a targeted immune response against malignant tumors.

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Authors and Affiliations

  1. National Science Center “Kharkov Institute of Physics and Technology”, ul. Akademicheskaya 1, Kharkiv, 61108, Ukraine

    V. A. Buts & K. P. Skibenko

  2. Institute of Radio Astronomy, National Academy of Sciences of Ukraine, ul. Krasnoznamennaya 4, Kharkiv, 61002, Ukraine

    V. A. Buts & K. P. Skibenko

  3. Karazin Kharkiv National University, pl. Svobody 4, Kharkiv, 61022, Ukraine

    V. A. Buts & K. P. Skibenko

Authors
  1. V. A. Buts
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  2. K. P. Skibenko
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Correspondence to V. A. Buts.

Additional information

Original Russian Text © V.A. Buts, K.P. Skibenko, 2018, published in Biofizika, 2018, Vol. 63, No. 3, pp. 462–467.

† Deceased.

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Buts, V.A., Skibenko, K.P. Use of Ultrasound for Creation of Highly Targeted Immune Response. BIOPHYSICS 63, 346–350 (2018). https://doi.org/10.1134/S0006350918030041

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  • DOI: https://doi.org/10.1134/S0006350918030041

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