The Effects of Hypoxic Hypoxia on Olfactory Sensitivity in Humans

Biophysics volume 63, pages463–468(2018)Cite this article

Abstract

This study examined the influence of hypoxic hypoxia on olfactory sensitivity in humans. Olfactory detection thresholds for n-butanol were studied when the subjects (male volunteers aged 18–20 years without ear, nose, or throat diseases and with low tolerance to hypoxia) breathed a hypoxic gas mixture. To mimic hypoxic hypoxia, participants were asked to breathe a gas mixture containing 10.5% oxygen. The oxygen level in the blood was controlled by the degree of hemoglobin oxygenation, as measured using a Nonin 9843 digital portable pulse oximeter (United States). The results of our study show that with a low fraction of inspired oxygen the olfactory detection thresholds for n-butanol increased (p ≤ 0.01). Therefore, a human olfactory receptor becomes less sensitive under hypoxic hypoxia.

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Affiliations

  1. Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia

    E. V. Bigdaj, E. A. Bezgacheva & V. O. Samojlov

  2. Arktika Scientific Research Center, Far East Branch, Russian Academy of Sciences, ul. K. Marksa 24, Magadan, 685000, Russia

    Y. N. Korolyev

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  1. E. V. Bigdaj
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  2. E. A. Bezgacheva
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  3. V. O. Samojlov
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  4. Y. N. Korolyev
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Correspondence to E. V. Bigdaj.

Additional information

Original Russian Text © E.V. Bigdaj, E.A. Bezgacheva, V.O. Samojlov, Y.N. Korolyev, 2018, published in Biofizika, 2018, Vol. 63, No. 3, pp. 598–605.

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Bigdaj, E.V., Bezgacheva, E.A., Samojlov, V.O. et al. The Effects of Hypoxic Hypoxia on Olfactory Sensitivity in Humans. BIOPHYSICS 63, 463–468 (2018). https://doi.org/10.1134/S000635091803003X

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Keywords

  • hypoxic hypoxia
  • olfaction
  • olfactory detection thresholds
  • olfactory testing