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Large-Scale Periodicities in the Nucleotide Sequences of Drosophila Early Developmental Gene Loci

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Abstract

An improved Fourier analysis and wavelet transform revealed a large-scale periodicity in the locations of sites with a characteristic local AT–GC composition in the nucleotide sequences of Drosophila early developmental genes. A localization of periodic locus sections indicated that they predominantly occur in transcription regulation modules (enhancers). The period lengths observed in ranges of 80–85, 165–180, and 330–400 nt agree well with the lengths typical of the nucleosomal level of chromatin organization. The harmonic periods in a range of 600–750 nt are approximately four nucleosomal repeats and are close to the minimum enhancer length typical of the Drosophila genome.

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References

  1. A. P. Lifanov, V. J. Makeev, A. G. Nazina, and D. A. Papatsenko, Genome Res. 4, 579 (2003).

    Article  Google Scholar 

  2. A. P. Lifanov, V. J. Makeev, and N. G. Esipova, Biophysics (Moscow) 60 (1), 10 (2015).

    Article  Google Scholar 

  3. A. P. Lifanov, V. J. Makeev, and N. G. Esipova, Biophysics (Moscow) 61 (1), 43 (2016).

    Article  Google Scholar 

  4. V. R. Chechetkin and A. Y. Turygin, J. Theor. Biol. 175, 477 (1995).

    Article  Google Scholar 

  5. R. C. Hardison and J. Taylor, Nat. Rev. Genet. 13 (7), 469 (2012).

    Article  Google Scholar 

  6. B. Salih, V. Tripathi and E. N. Trifonov, J. Biomol. Struct. Dyn. 33 (1), 1 (2015).

    Article  Google Scholar 

  7. L. Marino-Ramirez, M. G. Kann, B. A. Shoemaker, and D. Landsman, Expert Rev. Proteomics 2, 719 (2005).

    Article  Google Scholar 

  8. R. V. Hemming, Digital Filters (Sovetskoe Radio, Moscow, 1980) [in Russian].

    Google Scholar 

  9. R. U. Pathak, A. Srinivasan, and R. K. Mishra, BMC Genomics 15 (1), 1022 (2014).

    Article  Google Scholar 

  10. I. Daubechies, Ten Lectures on Wavelets: CBMS-NSF Regional Conference Series in Applied Mathematics, Vol. 6 (Philadelphia, PA, 1992).

    Book  Google Scholar 

  11. V. A. Namiot, A. V. Batyanovskii, I. V. Filatov, et al., Phys. Lett. A 375 (32), 2911 (2011).

    Article  ADS  Google Scholar 

  12. A. V. Batyanovskii, I. D. Volotovsky, V. A. Namiot, et al., Biophysics (Moscow) 60 (3), 348 (2015).

    Article  Google Scholar 

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Authors and Affiliations

  1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia

    A. P. Lifanov, G. I. Kravatskaya & N. G. Esipova

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  1. A. P. Lifanov
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  2. G. I. Kravatskaya
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  3. N. G. Esipova
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Correspondence to A. P. Lifanov.

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Lifanov, A.P., Kravatskaya, G.I. & Esipova, N.G. Large-Scale Periodicities in the Nucleotide Sequences of Drosophila Early Developmental Gene Loci. BIOPHYSICS 62, 1030–1032 (2017). https://doi.org/10.1134/S0006350917060124

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  • DOI: https://doi.org/10.1134/S0006350917060124

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