Abstract
Experiments with white rats were carried out to study the effects of original antithrombin DNA aptamers on the renal function and animal survival in rhabdomyolisis caused by intramuscular injection of a hyperosmolar glycerol solution. The DNA aptamers were demonstrated to exert a nephroprotective effect, reducing a retention azotemia and proteinuria, and improving the renal excretory function and overall survival of animals.
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Abbreviations
- AKI:
-
acute kidney injury
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Original Russian Text © I.I. Zamorskii, V.A. Spiridonova, 2017, published in Biofizika, 2017, Vol. 62, No. 2, pp. 405–408.
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Zamorskii, I.I., Spiridonova, V.A. The protective effects of antithrombin DNA aptamers in rhabdomyolysis. BIOPHYSICS 62, 321–323 (2017). https://doi.org/10.1134/S0006350917020294
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DOI: https://doi.org/10.1134/S0006350917020294