Abstract
The effects of Т1+ ions on the dynamics of intracellular Cа2+ in neonatal rat cardiomyocytes have been studied. It was shown for the first time that application of Т1+ led to an uncontrolled increase in [Cа2+]i in cells. Moreover, the ability of Т1+ to increase [Cа2+]i depended on the Т1+ concentration used and the time of exposure to the cells. The increase in [Cа2+]i was related to the entry of Cа2+ from the extracellular medium. Thallium did not release Cа2+ from intracellular stores. The thallium-induced increase in [Cа2+]i was not inhibited by nifedipine. It is possible that L-channels do not participate in the processes of thalliuminduced increase in [Cа2+]i. It is assumed that the thallium ions-induced calcium overload in cardiomyocytes may contribute to the toxic effect of Т1+ on the myocardium.
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Original Russian Text © C.V. Sobol, V.P. Nesterov, G.B. Belostotskaya, S.M. Korotkov, 2017, published in Biofizika, 2017, Vol. 62, No. 1, pp. 81–88.
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Sobol, C.V., Nesterov, V.P., Belostotskaya, G.B. et al. The effects of Tl+ ions on the dynamics of intracellular Ca2+ in rat cardiomyocytes. BIOPHYSICS 62, 68–74 (2017). https://doi.org/10.1134/S0006350917010201
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DOI: https://doi.org/10.1134/S0006350917010201