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Changes in the kinetics of plasma chemiluminescence as a measure of systemic oxidative stress in humans

  • Biophysics of Complex Systems
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Abstract

Oxidative stress acts as a pathogenetic factor in many diseases; estimating its level is important for early diagnosis and therapy adjustment. The antioxidant status was evaluated for the blood plasma. A set of chemiluminescence (CL) kinetic-curve parameters (latent period τlat and analytical signal increment ΔI CL) in a 2,2’-azo-bis(2-amidinopropane)dihydrochloride–luminol system were proposed for estimating the oxidative stress level. Uric acid and albumin were identified as major components that are responsible for the changes in the plasma CL kinetic curve. UV light caused oxidative modification of serum albumin in a dose-dependent manner, thus enhancing its antioxidant properties. Changes in plasma CL kinetics were proposed as a means to measure oxidative stress in the human body.

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Abbreviations

OS:

oxidative stress

CL:

chemiluminescence

ABAP:

2,2’-azo-bis(2-amidinopropane)dihydrochloride

HSA:

human serum albumin

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Authors and Affiliations

  1. Faculty of Basic Medicine, Moscow State University, Lomonosovskii prosp. 31/5, Moscow, 119192, Russia

    M. M. Sozarukova, A. M. Polimova, E. V. Proskurnina & Yu. A. Vladimirov

Authors
  1. M. M. Sozarukova
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  2. A. M. Polimova
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  3. E. V. Proskurnina
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  4. Yu. A. Vladimirov
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Corresponding author

Correspondence to M. M. Sozarukova.

Additional information

Original Russian Text © M.M. Sozarukova, A.M. Polimova, E.V. Proskurnina, Yu.A. Vladimirov, 2016, published in Biofizika, 2016, Vol. 61, No. 2, pp. 337–344.

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Sozarukova, M.M., Polimova, A.M., Proskurnina, E.V. et al. Changes in the kinetics of plasma chemiluminescence as a measure of systemic oxidative stress in humans. BIOPHYSICS 61, 284–290 (2016). https://doi.org/10.1134/S0006350916020202

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  • DOI: https://doi.org/10.1134/S0006350916020202

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