Abstract
The search for efficient radioprotective substances that alleviate various effects of ionizing radiation has been going on for more than 6 decades. The chronology of the major discoveries in this field and the changes in opinions, trends, and paradigms are considered in the present review. Various classes of chemical compounds that can be administered either before or after irradiation to protect biological objects from short- and long-term effects of ionizing radiation are considered. Dose-modifying factors, recommended time of administration, tissue specificity, and the toxicity of different classes of radioprotective substances are considered and the mechanisms that underlie the actions, as well as the practical applications, of these substances, are described. A section of this review is dedicated to future prospects and the directions of research on radioprotective substances.
Similar content being viewed by others
Abbreviations
- DMF:
-
dose-modifying factor
- RSH:
-
sulfhydryl radioprotectors
- SOD:
-
superoxide dismutase
- ACE:
-
angiotensin-1 converting enzyme
References
M. V. Vasin, Anti-Radiation Drugs (Ross. Akad. Poslediplomn. Obraz., 2010) [in Russian].
J. F. Weiss and M. R. Landauer, Int. J. Radiat. Biol. 85, 539 (2009).
H. B. Stone, J. E. Moulder, C. N. Coleman, et al., Radiat. Res. 162, 711 (2004).
M. V. Vasin, Radiats. Biol. Radioecol. 53, 459 (2013).
L. N. Shishkina, Radiats. Biol. Radioecol. 53, 536 (2013).
I. B. Ushakov and M. V. Vasin, Aviakosm. Ekol. Med. 45, 3 (2011).
H. M. Patt, E. B. Tyree, R. L. Straube, et al., Science 110, 213 (1949).
J. M. Yuhas and J. B. Storer, Int. J. Radiat. Biol. Rel. Stud. Phys. Chem. Med. 15, 233 (1969).
S. P. Tannehill and M. P. Mehta, Semin. Oncol. 23, 69 (1996).
D. Q. Brown, W. J. Graham, L. J. MacKenzie, et al., Pharmacol. Ther. 39, 157 (1988).
D. Doherty and W. Burnett, Proc. Soc. Exptl. Biol. Med. 89, 312 (1955).
M. R. Landauer, H. D. Davis, J. A. Dominitz, et al. Pharmacol. Therap. 39, 97 (1988).
Yu. N. Korystov and F. B. Vexler, Radiat. Res. 114, 550 (1988).
M. V. Vasin, Products for Prevention and Treatment of Radiation Injuries (VTsMK Zashchita, Moscow, 2006) [in Russian].
C. K. Nair, D. K. Parida, and T. Nomura, J. Radiat. Res. 42, 21 (2001).
H. Shen, Z. J. Chen, J. T. Zilfou, et al., J. Pharmacol. Exp. Therap. 297, 1067 (2001).
S. V. Gudkov, V. I. Bruskov, A. V. Kulikov, et al., Al’manakh Klin. Med. 31, 61 (2014).
J. T. Weil, J. Van der Veen, and H. S. Olcott, Nature 219, 168 (1968).
S. Tabaczar, M. Talar, and K. Gwoldzilski, Postepy Hig. Med. Dosw. 65, 46 (2011).
B. Halliwell, Free Radic. Res. 31, 261 (1999).
A. Petkau and W. S. Chelack, Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 26, 421 (1974).
M. Carpenter, S. H. Agarwal, S. H. Nie, et al., Int. J. Radiat. Oncol. Biol. Phys. 60, 172 (2004).
J. F. Weiss, Environ. Health Perspect. 105, 1473 (1997).
U. K. Alekperov and D. D. Akhundova, Genetika 10, 12 (1975).
M. I. Loseva, L. A. Purtova, and R. F. Gavalova, Kardiologiya 42, 48 (2002).
E. P. Cohen and E. C. Robbins, Semin. Nephrol. 23, 486 (2003).
A. Molteni, J. E. Moulder, E. F. Cohen, et al., Int. J. Radiat. Biol. 76, 523 (2000).
W. F. Ward, A. S. Hoellwarth, and R. D. Tuttle, Radiology 146, 533 (1983).
J. E. Moulder and B. L. Fish, Radiat. Oncol. Invest. 5, 50 (1997).
B. Wilson and T. Matsuzawa, Radiat. Res. 19, 231 (1963).
L. A. Il’in, I. E. Andrianova, V. A. Glushkov, et al., Radiats. Biol. Radioecol. 44, 547 (2004).
R. Neta, S. D. Douches, and J. J. Oppenheim, J. Immunol. 136, 2483 (1986).
F. Herodin, L. Roy, N. Grenier, et al., Exp. Hematol. 35, 1172 (2007).
P. Winczura and J. Jassem, Cancer Treatment Rev. 36, 268 (2010).
P. Stiff, W. Bensinger, T. Emmanouilides, and T. Gentile, Blood 102, 676 (2003).
A. A. Ivanov, V. P. Kuznetsov, A. M. Ulanova, et al., Radiats. Biol. Radioecol. 44, 403 (2004).
K. N. Prasad, Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 22, 187 (1972).
P. Needleman, J. Turk, A. R. Morrison, et al., Ann. Rev. Biochem. 55, 69 (1986).
W. R. Hanson, W. Zhen, L. Geng, et al., Radiat. Res. 142, 281 (1995).
M. Margoshes and B. L. Vallee, J. Am. Chem. Soc. 79, 4813 (1957).
J. Kagi and A. Schaffer, Biochemistry 27, 8509 (1988).
A. N. Koterov and I. V. Filippovich, Radiats. Biol. Radioecol. 35, 162 (1995).
R. Murata, Y. Nishimura, M. Hiraoka, et al., Radiat. Res. 143, 316 (1995).
P. J. Smith and C. O. Anderson, Int. J. Radiat. Biol. 46, 331 (1984).
R. F. Martin and N. Holmes, Nature 302, 452 (1983).
P. N. Lobachevsky, R. S. Vasireddy, S. Broadhurst, et al., Int. J. Radiat. Biol. 87, 274 (2011).
K. Mishra, R. Bhardwaj, and N. K. Chaudhury, Radiat. Res. 172, 698 (2009).
S. Chui and N. L. Oleinick, Radiat. Res. 149, 543 (1998).
R. D. Snyder and K. K. Schroeder, Radiat Res. 137, 67 (1994).
L. H. Gray, A. D. Conger, M. Ebert, et al., Br. J. Radiol. 26, 638 (1953).
M. S. Joyner and A. D. van der Kogel, Basic Clinical Radiobiology, 4th ed. (Hodder Education, London. 2009; Binom, Moscow, 2013).
L. Kh. Eidus and Yu. N. Korystov, Oxygen in Radiobiology (Energoatomizdat, Moscow, 1984) [in Russia].
S. Ya. Proskuryakov, N. G. Kucherenko, M. N. Semenenko, et al., Radiats. Biol. Radioecol. 43, 51 (2003).
M. V. Vasin, I. B. Ushakov, V. Yu. Kovtun, et al., Radiats. Biol. Radioecol. 48, 623 (2008).
A. N. Grebenyuk, V. V. Zatsepin, N. V. Aksenova, et al., Radiats. Biol. Radioecol. 50, 423 (2010).
F. Shimazu and A. L. Tappel, Radiat. Res. 23, 210 (1964).
B. Kumar, A. Kunwar, A. Ahmad, et al., Radiat. Environ. Biophys. 48, 379 (2009).
I. S. Drachev, V. I. Legeza, and Yu. S. Turlakov, Radiats. Biol. Radioecol. 53, 475 (2013).
A. Novick and L. Szilard, Nature 170, 926 (1952).
N. V. Luchnik, Biokhimiya 23, 146 (1958).
J. Maisin, P. Dumont, and A. Dunjio, Nature 186, 91 (1960).
K. S. Chertkov and V. M. Petrov, Aviakosm. Ekol. Med. 27, 27 (1993).
S. V. Gudkov, I. N. Shtarkman, V. S. Smirnova, et al., Radiat. Res. 165, 538 (2006).
S. V. Gudkov, O. Y. Gudkova, A. V. Chernikov, et al., Int. J. Radiat. Biol. 85, 116 (2009).
S. V. Gudkov, I. N. Shtarkman, V. S. Smirnova, A. V. Chernikov, and V. I. Bruskov, Dokl. Biochem Biophys. 407, 47 (2006).
N. R. Asadullina, A. M. Usacheva, and S. V. Gudkov, J. Radiat. Res. 53, 211 (2012).
N. R. Asadullina, A. M. Usacheva, V. S. Smirnova, et al., Nucleosides, Nucleotides, Nucleic Acids 29, 786 (2010).
N. R. Asadullina, S. V. Gudkov, and V. I. Bruskov, Dokl. Biochem. Biophys. 442, 22 (2012).
N. R. Popova, S. V. Gudkov, and V. I. Bruskov, Radiats. Biol. Radioecol. 54, 1 (2014).
H. W. Kroto, J. R. Heath, S. C. O’Brien, et al., Nature 318, 162 (1985).
P. J. Krusic, E. Wasserman, P. Keizer, et al., Science 254, 1183 (1991).
C. A. Theriot, R. C. Casey, V. C. Moore, et al., Radiat. Environ. Biophys. 49, 437 (2010).
V. Bogdanovic, K. Stankov, I. Icevic, et al., J. Radiat. Res. 49, 321 (2008).
S. Trajkovic, S. Dobric, V. Jacevic, et al., Colloids Surf. B 58, 39 (2007).
G. V. Andrievsky, V. I. Bruskov, A. A. Tykhomyrov, et al., Free Radic. Biol. Med. 47, 786 (2009).
A. P. Brown, E. J. Chung, M. E. Urick, et al., Radiat. Oncol. 5, 34 (2010).
S. K. Pirutin, V. B. Turovetskii, A. V. Kedrov, et al., Radiats. Biol. Radioecol. 52, 252 (2012).
S. V. Gudkov, A. V. Chernikov, and V. I. Bruskov, Ross. Khim. Zh. L, 73 (2014).
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © S.V. Gudkov, N.R. Popova, V.I. Bruskov, 2015, published in Biofizika, 2015, Vol. 60, No. 4, pp. 801–811.
Rights and permissions
About this article
Cite this article
Gudkov, S.V., Popova, N.R. & Bruskov, V.I. Radioprotective substances: History, trends and prospects. BIOPHYSICS 60, 659–667 (2015). https://doi.org/10.1134/S0006350915040120
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0006350915040120