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A new material based on collagen and taxifolin: Preparation and properties

  • Biophysics of Complex Systems
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Abstract

The possibility of producing a material based on collagen and a biologically active polyphenol, viz., taxifolin, was investigated, and the properties of the material were studied. The data on the release dynamics and metal-reducing activity of polyphenol that is chemically linked to collagen are represented. The effects of taxifolin, taxifolin glutarate, and a polyphenol-containing gel on the production of reactive oxygen species by neutrophils that are stimulated with phorbol myristate acetate were examined. Polyphenol that was released from the gel was shown to have antioxidant and metal-reducing properties. This suggests that unoxidized polyphenol is effectively included in the collagen gel.

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Abbreviations

PMA:

phorbol-12-myristate-13-acetate

DMTMM:

4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride

ROS:

reactive oxygen species

LDC:

luminol-dependent chemiluminescence

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Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow Region, 142290, Russia

    Yu. V. Shatalin & V. S. Shubina

  2. Pushchino State Institute of Natural Sciences, pr. Nauki 3, Pushchino, Moscow Region, 142290, Russia

    Yu. V. Shatalin & V. S. Shubina

Authors
  1. Yu. V. Shatalin
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  2. V. S. Shubina
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Correspondence to Yu. V. Shatalin.

Additional information

Original Russian Text © Yu.V. Shatalin, V.S. Shubina, 2015, published in Biofizika, 2015, Vol. 60, No. 3, pp. 583–588.

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Shatalin, Y.V., Shubina, V.S. A new material based on collagen and taxifolin: Preparation and properties. BIOPHYSICS 60, 474–478 (2015). https://doi.org/10.1134/S0006350915030173

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  • DOI: https://doi.org/10.1134/S0006350915030173

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