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Simulation of the fibroblast effect on electrical activity of sinoatrial node cells

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Abstract

It was found via the mathematical simulation of the effect of fibroblasts on the electrical activity of the sinoatrial node cells that the interaction with fibroblasts through gap junctions increases the oscillation frequency of pacemakers. Under the effect of fibroblasts, the oscillation amplitude of a true pacemaker decreases until the end of the spontaneous activity. The oscillation amplitude of a latent pacemaker decreases considerably less.

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Authors and Affiliations

  1. Moscow Institute of Physics and Technology (State University), Dolgoprudnyi, Moscow oblast, 141700, Russia

    A. S. Tolstokorov, R. A. Syunyaev & R. R. Aliev

  2. Research Institute of Cardiology, Federal Research and Clinical Center, Federal Medical-Biological Agency of Russia, Moscow, 115682, Russia

    A. S. Tolstokorov, R. A. Syunyaev & R. R. Aliev

  3. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia

    R. A. Syunyaev & R. R. Aliev

Authors
  1. A. S. Tolstokorov
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  2. R. A. Syunyaev
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  3. R. R. Aliev
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Corresponding author

Correspondence to R. A. Syunyaev.

Additional information

Original Russian Text © A.S. Tolstokorov, R.A. Syunyaev, R.R. Aliev, 2015, published in Biofizika, 2015, Vol. 60, No. 2, pp. 322–329.

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Tolstokorov, A.S., Syunyaev, R.A. & Aliev, R.R. Simulation of the fibroblast effect on electrical activity of sinoatrial node cells. BIOPHYSICS 60, 256–262 (2015). https://doi.org/10.1134/S0006350915020190

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  • DOI: https://doi.org/10.1134/S0006350915020190

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