Abstract
The effective accumulation of binuclear dinitrosyl iron complexes with glutathione was shown after subcutaneous perilymphatic injection of an aqueous solution of dinitrosyl iron complexes into animal lung tissue at a single dose of 2 µmol per kg twice a day with an interval of 2 h. At 2 hours after the repeated administration, the concentration of these complexes was 16 µmol per kg of the tissue, which decreased during the last 2 hours to 7 μmol per kg of the tissue. Upon a single injection of binuclear dinitrosyl iron complexes with glutathione, their concentration 2 and 4 hours later was two times lower than that in the previous experiments. Presumably, at the obtained concentrations of dinitrosyl iron complexes, a bactericidal effect in the lungs could be observed against Mycobacterium tuberculosis and rapidly proliferating lung tumors.
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Original Russian Text © G.N. Mojokina, N.A. Elistratova, V.D. Mikoyan, A.F. Vanin, 2015, published in Biofizika, 2015, Vol. 60, No. 2, pp. 355–359.
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Mojokina, G.N., Elistratova, N.A., Mikoyan, V.D. et al. The delivery of dinitrosyl iron complexes into animal lungs. BIOPHYSICS 60, 284–287 (2015). https://doi.org/10.1134/S0006350915020116
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DOI: https://doi.org/10.1134/S0006350915020116