Abstract
Expression patterns of segmentation genes form under the influence of gradients of maternal transcription factors, which initiate spatially local expression in the segmentation gene cascade. Bcd acts as one of these activators. A model of the regulation in the gap-gene network was studied by varying the Bcd concentration. The topology that is known for the gap-gene network was found to be insufficient for explaining the experimental finding that the hb anterior expression domain shifts when the Bcd concentration changes in the embryo. Modeling that was performed to comply with this experimental finding yielded a new topology, which determined the proper shifts of the hb expression domain. The result indicates that interactions of hb, Kr, and gt act as key regulatory factors to ensure the correct behavior of the hb expression pattern upon changes in Bcd concentration. This study made it possible to specify the limits of the validity of phenomenological models of gene networks.
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Abbreviations
- AP:
-
anteroposterior
References
W. Driever and C. Nusslein-Volhard, Cell 54, 83 (1988).
M. Hulskamp, C. Schroder, C. Pfeifle, et al., Nature 338, 629 (1989).
D. Weigel, G. Jurgens, M. Klingler, and H. Jackle, Science 248 (4954), 495 (1990).
P. W. Ingham, Nature 335, 25 (1988).
S. M. Cohen and G. Jurgens, Nature 346, 482 (1990).
U. Grossniklaus, K. M. Cadigan, and W. J. Gehring, Development 120 (11), 3155 (1994).
A. Vincent, J. T. Blankenship, and E. Wieschaus, Development 124, 747 (1997).
J. T. Blankenship and E. Wieschaus, Development 128, 5129 (2001).
L. Wolpert, J. Theor. Biol. 25, 1 (1969).
H. G. Frohnhofer, R. Lehmann, and C. Nusslein-Volhard, J. Embryol. Exp. Morphol. 97 (Suppl.), 169 (1986).
W. Driever and C. Nusslein-Volhard, Cell 54, 95 (1988).
B. Houchmandzadeh, E. Wieschaus, and S. Leibler, Nature 415, 798 (2002).
S. Bergmann, O. Sandler, H. Sberro, et al., PLoS Biol. 5 (2), e46 (2007).
F. Liu, A. H. Morrison, and T. Gregor, Proc. Natl. Acad. Sci. U. S. A. 110 (17), 6724 (2013).
E. Mjolsness, J. Reinitz, and D. H. Sharp, J. Theor. Biol. 152, 429 (1991).
J. Jaeger, et al., Nature 430, 368 (2004).
Manu, et al., PloS Biol. 7, e1000049 (2009).
K. N. Kozlov, S. Surkova, E. Myasnikova, et al., PLoS Comput. Biol. 8, e1002635 (2012).
Manu, S. Surkova, A. V. Spirov, et al., PLoS Comput. Biol. 5, e1000303 (2009).
V. V. Gursky, L. Panok, E. M. Myasnikova, et al., BMC Syst. Biol. 5, 118 (2011).
C. Nusslein-Volhard, H. G. Frohnhofer, and R. Lehmann, Science 238, 1675 (1987).
V. V. Gursky, K. N. Kozlov, A. M. Samsonov, and J. Reinitz, Biophysics (Moscow) 53 (2), 164 (2008).
J. Jaeger, Cell. Mol. Life Sci. 68, 243 (2011).
S. Surkova, D. Kosman, K. N. Kozlov, et al., Dev. Biol. 313 (2), 844 (2005).
J. S. Margolis, M. L. Borowsky, E. Steingrimsson, et al., Development 121, 3067 (1995).
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Original Russian Text © S.A. Andreev, M.G. Samsonova, V.V. Gursky, 2015, published in Biofizika, 2015, Vol. 60, No. 2, pp. 225–233.
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Andreev, S.A., Samsonova, M.G. & Gursky, V.V. Modeling of the Drosophila gap-gene network with the variation of the Bcd morphogen. BIOPHYSICS 60, 173–180 (2015). https://doi.org/10.1134/S0006350915020025
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DOI: https://doi.org/10.1134/S0006350915020025