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Photophysical properties and photodynamic activity of nanostructured aluminum phthalocyanines

  • Molecular Biophysics
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Abstract

Water-soluble supramolecular complexes of aluminum phthalocyanines with rare photoactive nano-aggregates were developed on the basis of mesoporous silica nanoparticles (AlCl-Pc-nSiO2) and polyvinylpyrrolidone (AlCl-Pc-PVP). Radiative lifetimes, extinction coefficients, and electron transition energies were calculated for isolated and associated metal phthalocyanine complexes. Nontoxic concentrations were determined for the synthetic nanocomposite photosensitizers in vitro. The photodynamic treatment efficacy was compared for three aluminum phthalocyanine modifications: Photosens®, AlCl-Pc-nSiO2, and AlCl-Pc-PVP. Mesenchymal stromal cells were used as a model for photodynamic treatment. The most efficient intracellular accumulation was observed for AlCl-Pc-nSiO2. Illumination of phthalocyanine-loaded cells led to a generation of reactive oxygen species and subsequent apoptotic cell death. Silica nanoparticles provided for a significant decrease in effective phthalocyanine concentration and enhanced cytotoxicity of photodynamic treatment.

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Abbreviations

MPc:

metal phthalocyanine complex

PDT:

photodynamic treatment

PVP:

polyvinylpyrrolidone

nSiO2 :

silica nanoparticles

MMSC:

multipotent mesenchymal stromal cell

AlCl-Pc:

aluminum chloride phthalocyanine

AlCl-Pc-nSiO2 :

AlCl-Pc supramolecular complexes based on nSiO2

AlCl-Pc-PVP:

AlCl-Pc supramolecular complexes based on PVP

LUMO:

lowest unoccupied molecular orbital

HOMO:

highest occupied molecular orbital

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Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia

    O. O. Udartseva, E. R. Andreeva & L. B. Buravkova

  2. Semenov Institute of Chemical Physics, Moscow, 119991, Russia

    A. V. Lobanov & G. S. Dmitrieva

  3. Chemical Faculty, Moscow State University, Moscow, 119991, Russia

    M. Ya. Mel’nikov

Authors
  1. O. O. Udartseva
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  2. A. V. Lobanov
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  3. E. R. Andreeva
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  4. G. S. Dmitrieva
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  5. M. Ya. Mel’nikov
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  6. L. B. Buravkova
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Corresponding author

Correspondence to O. O. Udartseva.

Additional information

Original Russian Text © O.O. Udartseva, A.V. Lobanov, E.R. Andreeva, G.S. Dmitrieva, M.Ya. Mel’nikov, L.B. Buravkova, 2014, published in Biofizika, 2014, Vol. 59, No. 6, pp. 1051–1060.

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Udartseva, O.O., Lobanov, A.V., Andreeva, E.R. et al. Photophysical properties and photodynamic activity of nanostructured aluminum phthalocyanines. BIOPHYSICS 59, 854–860 (2014). https://doi.org/10.1134/S0006350914060244

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  • DOI: https://doi.org/10.1134/S0006350914060244

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