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On efficient in vitro purification of cell suspensions containing malignant cells

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Abstract

We have suggested a method for magnetic sorting of cell suspensions capable of differentiating not only the cells with a single specific antigen on their surface, but also those with a group of given antigens. Individually, each antigen of this group could be present on the surfaces of undesired cells. However, only the simultaneous presence of all the given antigens on the cell surface indicates that such a cell should be separated. The method is of interest for purification of cell suspensions from malignant cells—in particular, for purification of bone marrow material for autologous transplantation in leukemia.

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Authors and Affiliations

  1. Institute of Nuclear Physics, Moscow State University, Moscow, 119991, Russia

    V. A. Namiot

  2. Sechenov Moscow Medical Academy, ul. Malaya Trubetskaya 8, Moscow, 119881, Russia

    E. A. Kogan

  3. Moscow Institute of Physics and Technology, Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700, Russia

    I. V. Filatov

  4. Vavilov Institute of General Genetics, Russian Academy of Sciences, ul. Gubkina 3, Moscow, 119991, Russia

    M. S. Polishchuk

  5. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia

    V. G. Tumanyan & N. G. Esipova

Authors
  1. V. A. Namiot
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  2. E. A. Kogan
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  3. I. V. Filatov
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  4. M. S. Polishchuk
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  5. V. G. Tumanyan
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  6. N. G. Esipova
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Corresponding author

Correspondence to N. G. Esipova.

Additional information

Original Russian Text © V.A. Namiot, E.A. Kogan, I.V. Filatov, M.S. Polishchuk, V.G. Tumanyan, N.G. Esipova, 2014, published in Biofizika, 2014, Vol. 59, No. 6, pp. 1121–1124.

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Namiot, V.A., Kogan, E.A., Filatov, I.V. et al. On efficient in vitro purification of cell suspensions containing malignant cells. BIOPHYSICS 59, 910–912 (2014). https://doi.org/10.1134/S0006350914060128

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  • DOI: https://doi.org/10.1134/S0006350914060128

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