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Changes in the hemoporphyrin conformation in hemoglobin and NO-binding in erythrocytes under the action of insulin-like growth factor 1

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Abstract

The paper presents data on the effect of different concentrations of insulin-like growth factor 1 on a state of human erythrocytes. Changes in the hemoglobin conformation, the erythrocyte NO-binding function, and microviscosity of the plasma membrane were observed under activation of the cell receptors to insulin-like growth factor 1. It was shown for the first time that, when the insulin-like growth factor 1 molecules bind to the cell surface, the hemoglobin conformation in erythrocytes and its affinity to ligands are changed.

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Authors and Affiliations

  1. Faculty of Biology, Moscow State University, Moscow, 119991, Russia

    S. S. Kovalenko, E. Yu. Parshina, A. I. Yusipovich, G. V. Maksimov & A. B. Rubin

Authors
  1. S. S. Kovalenko
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  2. E. Yu. Parshina
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  3. A. I. Yusipovich
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  4. G. V. Maksimov
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  5. A. B. Rubin
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Corresponding author

Correspondence to S. S. Kovalenko.

Additional information

Original Russian Text © S.S. Kovalenko, E.Yu. Parshina, A.I. Yusipovich, G.V. Maksimov, A.B. Rubin, 2014, published in Biofizika, 2014, Vol. 59, No. 6, pp. 1093–1096.

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Kovalenko, S.S., Parshina, E.Y., Yusipovich, A.I. et al. Changes in the hemoporphyrin conformation in hemoglobin and NO-binding in erythrocytes under the action of insulin-like growth factor 1. BIOPHYSICS 59, 887–889 (2014). https://doi.org/10.1134/S0006350914060062

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  • DOI: https://doi.org/10.1134/S0006350914060062

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