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Nonspecific effect of Na+/K+-ATPase inhibition with strophanthin or under hypothermia in rat heart

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Abstract

Electron probe microanalysis was applied to study the kinetics of changes in potassium and sodium concentration in muscle cells of isolated heart from Wistar rat during experimental ischemia. Hypoxic perfusion without glucose was shown to evoke the potassium deficiency and sodium accumulation in cardiac myocells. Short-term action (10 min) of strophanthin (0.1 mM/L) recovered Na/K balance in ischemic myocells. Hypothermic perfusion exhibited the opportunity to conserve the cytoplasmic elemental contents in the state corresponding to the beginning of low temperature (4°C) operation.

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Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia

    V. N. Pogorelova, A. I. Panait & A. G. Pogorelov

Authors
  1. V. N. Pogorelova
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  2. A. I. Panait
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  3. A. G. Pogorelov
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Corresponding author

Correspondence to A. G. Pogorelov.

Additional information

Original Russian Text © V.N. Pogorelova, A.I. Panait, A.G. Pogorelov, 2014, published in Biofizika, 2014, Vol. 59, No. 5, pp. 946–950.

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Pogorelova, V.N., Panait, A.I. & Pogorelov, A.G. Nonspecific effect of Na+/K+-ATPase inhibition with strophanthin or under hypothermia in rat heart. BIOPHYSICS 59, 768–771 (2014). https://doi.org/10.1134/S0006350914050212

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  • DOI: https://doi.org/10.1134/S0006350914050212

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