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Arp2/3 complex is involved in the effect of glutoxim and molixan on intracellular Ca2+ concentration in macrophages

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Abstract

The involvement of Arp2/3 complex, which causes actin filament branching, in the effect of drugs glutoxim and molixan on intracellular Ca2+ concentration was investigated. Using Fura-2AM microfluorimetry it was shown for the first time that Arp2/3 complex inhibitor CK-0944666 almost completely prevents the increase in intracellular Ca2+ concentration, induced by glutoxim or molixan in macrophages. The data suggest the involvement of Arp2/3 complex in the glutoxim and molixan effect on the Ca2+ signaling processes in macrophages.

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Authors and Affiliations

  1. St. Petersburg State University, St. Petersburg, 199034, Russia

    L. S. Milenina, Z. I. Krutetskaya, A. A. Naumova, N. I. Krutetskaya, S. N. Butov & V. G. Antonov

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  1. L. S. Milenina
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  2. Z. I. Krutetskaya
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  3. A. A. Naumova
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  4. N. I. Krutetskaya
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  5. S. N. Butov
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  6. V. G. Antonov
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Corresponding author

Correspondence to L. S. Milenina.

Additional information

Original Russian Text © L.S. Milenina, Z.I. Krutetskaya, A.A. Naumova, N.I. Krutetskaya, S.N. Butov, V.G. Antonov, 2014, published in Biofizika, 2014, Vol. 59, No. 5, pp. 907–912.

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Milenina, L.S., Krutetskaya, Z.I., Naumova, A.A. et al. Arp2/3 complex is involved in the effect of glutoxim and molixan on intracellular Ca2+ concentration in macrophages. BIOPHYSICS 59, 736–740 (2014). https://doi.org/10.1134/S0006350914050170

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  • DOI: https://doi.org/10.1134/S0006350914050170

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