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Information theory of ageing: Studying the effect of bone marrow transplantation on the life span of mice

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Abstract

In this paper the method of life span extension of multicellular organisms (human) using reservation of stem cells followed by autotransplantation has been proposed. As the efficiency of this method results from the information theory of ageing, it is important to verify it experimentally testing the basic concepts of the theory. Taking it into consideration, the experiment on bone marrow transplantation to old mice from young closely related donors of the inbred line was carried out. It has been shown that transplanted animals exhibited a survival advantage, a mean life span increased by 34% as compared to the control. This result not only demonstrates the efficiency of the proposed method for life span extension of multicellular organisms, but also confirms the basis of the information theory of ageing.

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Authors and Affiliations

  1. Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia

    A. V. Karnaukhov, E. V. Karnaukhova, L. A. Sergievich, N. A. Karnaukhova, I. A. Manokhina & V. N. Karnaukhov

  2. Institute of General Pathology and Pathophysiology Russian Academy of Medical Sciences, Moscow, 125315, Russia

    E. V. Bogdanenko

  3. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia

    A. A. Smirnov

Authors
  1. A. V. Karnaukhov
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  2. E. V. Karnaukhova
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  3. L. A. Sergievich
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  4. N. A. Karnaukhova
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  5. E. V. Bogdanenko
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  6. A. A. Smirnov
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  7. I. A. Manokhina
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  8. V. N. Karnaukhov
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Correspondence to A. V. Karnaukhov.

Additional information

Original Russian Text © A.V. Karnaukhov, E.V. Karnaukhova, L.A. Sergievich, N.A. Karnaukhova, E.V. Bogdanenko, A.A. Smirnov, I.A. Manokhina, V.N. Karnaukhov, 2014, published in Biofizika, 2014, Vol. 59, No. 4, pp. 790–795.

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Karnaukhov, A.V., Karnaukhova, E.V., Sergievich, L.A. et al. Information theory of ageing: Studying the effect of bone marrow transplantation on the life span of mice. BIOPHYSICS 59, 646–650 (2014). https://doi.org/10.1134/S0006350914040137

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  • DOI: https://doi.org/10.1134/S0006350914040137

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