Abstract
Changes in the state of the central nervous system, leading to the development of pathological processes, directly are associated with a state of neurons, particularly with their conductivity in synaptic cleft region. The synaptic flexibility plays a key role in environmental adaptation, which manifests in dynamic changes of synaptic properties. However more attention was paid rather to their functional, than physical-chemical properties. We present the results of simulation of potential determining ions in synaptic contact area using Langevin dynamics. Diffusion and self-diffusion coefficients were calculated. It is shown that the range of variability of the diffusion coefficient of ions in perimembrane space, caused by variable viscosity and dielectric conductivity of electrolyte can reach 20%. These physical-chemical synaptic parameters can be considered as relevant for synaptic flexibility.
Similar content being viewed by others
References
J. F. Park and Z. D. Luo, Channels 4, 510 (2010).
M. J. Kennedy and M. D. Ehlers, Ann. Rev. Neurosci. 29, 325 (2006).
M. A. Sutton and E. M. Schuman, Cell 127, 49 (2006), ISSN 00928674
D. A. Feldheim, Y. I. Kim, A. D. Bergeman, et al., Nat. Rev. Neurosci. 4, 456 (2003).
R. C. Malenka, Ann. N.Y. Acad. Sci. 1003, 1 (2003), ISSN 1749-6632.
R. Frischknecht, M. Heine, D. Perrais, et al., Nature Neurosci. 12, 897 (2009).
C. V. Ly and P. Verstreken, Neurosci. 12, 291 (2006).
Y. Yarom and J. Hounsgaard, Physiol. Rev. 91, 917 (2011).
S. Boronovsky, I. Seraya, and Y. Nartsissov, Systems Biology, IEE Proceedings 153, 394 (2006), ISSN 1741-2471.
S. Boronovsky and Y. Nartsissov, Biophysics 54, 312 (2009), ISSN 0006-3509.
R. Balesku, Equilibrium and Non-equilibrium Statistical Mechanics (Mir, Moscow, 1978) [in Russian].
T. Erdei-Gruz, Transfer Phenomena in Water Solutions (Mir, Moscow, 1976) [in Russian].
J. H. Chen and S. A. Adelman, J. Chem. Phys. 72, 2819 (1980).
J. Barthel, K. Bachhuber, R. Buchner, and H. Hetzenauer, Chem. Phys. Lett. 165, 369 (1990).
J.-C. Bollinger and T. Yvernault, J. Solution Chem. 14, 605 (1985).
S. H. Lee and J. C. Rasaiah, J. Chem. Phys. 101, 6964 (1994).
D. A. Turchenkov and M. A. Turchenkov, Kompyut. Isseld. Modelir. 4, 2 (2012).
S. Koneshan, J. C. Rasaiah, R. M. Lynden-Bell, and S. H. Lee, J. Phys. Chem. B 102, 4193 (1998).
D. Jiao, C. King, A. Grossfield, et al., J. Phys. Chem. B 110, 18553 (2006).
S. Amira, D. Spangberg, M. Probst, and K. Hermansson, J. Phys. Chem. B 108, 496 (2004).
D. E. Goldsack and R. Franchetto, Can. J. Chem. 55, 1062 (1977).
P. Wang and A. Anderko, Fluid Phase Equilibria 186, 103 (2001).
F. E. Harris and C. T. O’Konski, J. Phys. Chem. 61, 310 (1957).
J. B. Hasted, D. M. Ritson, and C. H. Collie, J. Chem. Phys. 16, 1 (1948).
S. H. Lee and J. C. Rasaiah, J. Phys. Chem. 100, 1420 (1996).
V. M. Pokrovskii, Human Physiology (Meditsina, 2003) [in Russian].
R. Schmidt and G. Thews, Human Physiology (Springer-Verlag, 1989), ISBN 9780387194325.
L. Squire, Fundamental Neuroscience (Academic Press, 2003), ISBN 9780126603033.
R. O. Calderon, B. Attema, and G. H. DeVries, J. Neurochem. 64, 424 (1995), ISSN 1471-4159.
R. B. Schoch, J. Han, and P. Renaud, Rev. Mod. Phys. 80, 839 (2008).
N. Akaike and M. Kaneda, J. Neurophys. 62, 1400(1989).
E. R. Nightingale, J. Phys. Chem. 63, 1381 (1959).
S. Obst and H. Bradaczek, J. Phys. Chem. 100, 15677 (1996).
S. Chowdhuri and A. Chandra, J. Chem. Phys. 118, 9719 (2003).
Z.-Z. Yang and X. Li, J. Phys. Chem. A 109, 3517 (2005).
L. Yuan-Hui and S. Gregory, Geochim. Cosmochim. Acta 38, 703 (1974).
R. Mills and V. Lobo, Phys. Sci. Data (Elsevier, 1989), ISBN 9780444416896.
J. H. Wang and S. Miller, J. Am. Chem. Soc. 74, 1611 (1952).
K. Tanaka and M. Nomura, J. Chem. Soc., Faraday Trans. 1 83, 1779 (1987).
A. M. Friedman and J. W. Kennedy, J. Am. Chem. Soc. 77, 4499 (1955).
J. H. Wang, J. Am. Chem. Soc. 74, 1612 (1952).
R. Mills, J. Phys. Chem. 61, 1631 (1957).
R. Mills and A. W. Adamson, J. Am. Chem. Soc. 77, 3454 (1955).
J. H. Wang, J. Am. Chem. Soc. 75, 1769 (1953).
P. A. Lyons and J. F. Riley, J. Am. Chem. Soc. 76, 5216 (1954).
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © D.A. Turchenkov, S.E. Boronovsky, Ya.R. Nartsissov, 2013, published in Biofizika, 2013, Vol. 58, No. 6, pp. 1013–1021.
Rights and permissions
About this article
Cite this article
Turchenkov, D.A., Boronovsky, S.E. & Nartsissov, Y.R. Model of ion diffusion in synaptic cleft based on stochastical integration of langevin equation at dielectric friction approximation. BIOPHYSICS 58, 796–803 (2013). https://doi.org/10.1134/S0006350913060195
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0006350913060195