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Study of membranotropic and antioxidant activity of flavonoids and their complexes with ferric iron

  • Cell Biophysics
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Abstract

We studied the interaction with liposomes and the antioxidant activity of flavonoid (quercetin, catechin, taxifolin) complexes with iron(III). It was found that the lipophilicity of complexes depends on an iron:flavonoid ratio and grows at a ratio of 1 to 1, while complexes in a 2: 1 ratio were the most effective to slow down the lipid peroxidation and restore radical 2,2-diphenyl-1-picrylhydrazyl. Thus, the stoichiometry of complexes formed in aqueous solution, may differ from the stoichiometry of complexes that most effectively protect membranes from peroxidation.

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Authors and Affiliations

  1. Tula State University, Tula, 300600, Russia

    E. A. Yagolnik & E. N. Muzafarov

  2. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia

    Yu. S. Tarahovsky & S. M. Kuznetsova

  3. Institute of Fundamental Problems of Biology, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia

    I. B. Klenina

  4. Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia

    Yu. A. Kim

Authors
  1. E. A. Yagolnik
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  2. Yu. S. Tarahovsky
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  3. I. B. Klenina
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  4. S. M. Kuznetsova
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  5. E. N. Muzafarov
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  6. Yu. A. Kim
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Corresponding author

Correspondence to E. A. Yagolnik.

Additional information

Original Russian Text © E.A. Yagolnik, Yu.S. Tarahovsky, I.B. Klenina, S.M. Kuznetsova, E.N. Muzafarov, Yu.A. Kim, 2013, published in Biofizika, 2013, Vol. 58, No. 5, pp. 819–827.

Editor’s Note: This is a closest equivalent of the original publication with all its practical details, statements and terminology, phrasing and style; English title and Abstract provided by authors. A.G.

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Yagolnik, E.A., Tarahovsky, Y.S., Klenina, I.B. et al. Study of membranotropic and antioxidant activity of flavonoids and their complexes with ferric iron. BIOPHYSICS 58, 646–652 (2013). https://doi.org/10.1134/S0006350913050187

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  • DOI: https://doi.org/10.1134/S0006350913050187

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