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Features of the metabolism of nitric oxide in normal state and inflammation

  • Complex Systems Biophysics
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Abstract

Brief analysis of the metabolism of nitric oxide in living cells in normal state and pathology and also the analysis of the causes that hampered the progress of these studies were carried out. It was established that most of physiological fluids, including blood, normally contain nitrite and non-thiolate nitroso compounds in concentration less than 100 nM. Literature data from different researchers on the normal range of nitrite concentration in plasma of healthy people from several hundreds of nM to several μM is probably the result of low selectivity of the methods used. But nitrite and non-thiolate nitroso compounds concentration in blood is dramatically increased in case of inflammatory diseases. It is proposed that the main mechanism for the production of these substances in blood is the nitrosyl iron complexes transformation by active oxygen species but not the activation of NO production as it was considered previously.

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Authors and Affiliations

  1. Pirogov Russian National Research Medical University, Moscow, 117997, Russia

    V. Yu. Titov, A. N. Osipov & M. V. Kreinina

  2. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, 119991, Russia

    A. F. Vanin

Authors
  1. V. Yu. Titov
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  2. A. N. Osipov
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  3. M. V. Kreinina
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  4. A. F. Vanin
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Additional information

Original Russian Text © V.Yu. Titov, A.N. Osipov, M.V. Kreinina, A.F. Vanin, 2013, published in Biofizika, 2013, Vol. 58, No. 5, pp. 857–870.

Editor’s Note: I certify that this is a closest equivalent of the original publication with all its factual statements and terminology, phrasing and style; English title and Abstract provided by authors. A.G.

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Titov, V.Y., Osipov, A.N., Kreinina, M.V. et al. Features of the metabolism of nitric oxide in normal state and inflammation. BIOPHYSICS 58, 676–688 (2013). https://doi.org/10.1134/S0006350913050163

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