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Influence of receptor lateral diffusion on depression of neuronal cholinosensitivity

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Abstract

Using mathematical model a comparative analysis of the influence of receptor lateral diffusion, endocytosis and exocytosis of receptors on the change in the number of membrane receptors at rhythmical local applications of a mediator on neural soma was performed. The results allow us to estimate quantitatively the effect of these processes on the length of the period between mediator applications. The necessity of considering the change in the rate of receptor lateral diffusion, while studying the effect of some protein kinases and protein phosphatases on the change in the number of receptors, became evident. The model also provided the effect of “after stimulus efficiency.”

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Authors and Affiliations

  1. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, 117485, Russia

    G. B. Murzina

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  1. G. B. Murzina
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Correspondence to G. B. Murzina.

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Original Russian Text © G.B. Murzina, 2013, published in Biofizika, 2013, Vol. 58, No. 3, pp. 516–523.

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Murzina, G.B. Influence of receptor lateral diffusion on depression of neuronal cholinosensitivity. BIOPHYSICS 58, 402–408 (2013). https://doi.org/10.1134/S000635091303010X

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  • DOI: https://doi.org/10.1134/S000635091303010X

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