Abstract
Changes in Fe3+-transferrin (Fe-Tf) and Cu2+-ceruloplasmin (Cu-Cp) concentrations in venous blood sampled from anemic patients with urinary bladder and kidney cancer of stages I–IV were assessed using EPR spectroscopy. In malignancy-associated anemia, the paramagnetic Fe3+ concentration in Tf proved to be below the norm, while in anemic non-oncology patients the Tf iron saturation was normal. Moreover, in patients with malignancy-associated anemia the Cu-Cp on average was nearly twice higher than in healthy volunteers (p < 0.01). Thus, simultaneous EPR measurement of protein-borne paramagnetic centers (such as Fe-Tf and Cu-Cp) in the blood of anemic patients can be used as an express biomarker for urological cancer even at early stages of malignant growth.
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Original Russian Text © M.I. Ibragimova, A.I. Chushnikov, V.N. Moiseev, V.Yu. Petukhov, E.P. Zheglov, G.V. Cherepnev, 2013, published in Biofizika, 2013, Vol. 58, No. 2, pp. 289–294.
The experimental data contained herein fully correspond to the original publication but the text had to be substantially revised for the English version. A.G.
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Ibragimova, M.I., Chushnikov, A.I., Moiseev, V.N. et al. EPR study of blood of anemic patients with urological cancer. BIOPHYSICS 58, 212–215 (2013). https://doi.org/10.1134/S0006350913020097
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DOI: https://doi.org/10.1134/S0006350913020097