Abstract
The effects of small size (∼2 nm) gold nanoparticles on the properties of particles of cholesteric liquid-crystalline dispersions formed by double-stranded DNA molecules were analyzed. It has been shown that gold nanoparticles induce two different processes. First, they facilitate reorganization of the spatial cholesteric structure of dispersion particles to nematic one. This process is accompanied by the fast decrease in the amplitude of abnormal band in the CD spectrum. Second, they can form ensembles consisting of gold nanoparticles. This process is accompanied by the development and displacement of surface plasmon resonance band in the visible region of the absorption spectrum. The appearance of this band is analyzed by considering two different models of the formation of ensembles consisting of gold nanoparticles. By small-angle X-ray scattering we performed structural analysis of phases formed by DNA cholesteric liquid-crystalline dispersion particles treated with gold nanoparticles. As a result of this study it was possible to prove the formation of linear clusters of gold nanoparticles in the “free space” between the adjacent DNA molecules fixed in the quasinematic layers of liquid-crystalline particles. It has been hypothesized that the formation of linear clusters of gold nanoparticles is most likely related to DNA molecules, ordered in the spatial structure of quasinematic layers, and the toxicity of these nanoparticles in biological systems hypothesized.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
L. A. Dykman, V. A. Bogatyrev, S. Yu. Shchegolev, and N. G. Khlebtsov, Gold Nanoparticles: Synthesis, Properties, Biomedical Application (Nauka, Moscow, 2008) [in Russian].
B. Kang, M. A. Mackey, and M. A. El-Sayed, J. Am. Chem. Soc. 132(5), 1517 (2010).
M. Tsoli, H. Kuhn, W. Brandau, et al., Small 1(8–9), 841 (2005).
Yu. M. Yevdokimov, V. I. Salyanov, S. V. Semenov, and S. G. Skuridin, Liquid-Crystal Dispersions and Nanoconstructs of DNA (Radiotekhnika, Moscow, 2008) [in Russian].
F. Livolant and A. Leforestier, Prog. Polym. Sci. 21(6), 1115 (1996).
A. Leforestier and F. Livolant, Proc. Natl. Acad. Sci. USA 106(23), 9157 (2009).
A. Leforestier and F. Livolant, J. Mol. Biol. 396(2), 384 (2010).
D. G. Duff, A. Baiker, and P. P. Edwards, Langmuir 9(9), 2301 (1993).
L. Yu. Mogilevskii, A. T. Dembo, D. I. Svergun, and L. A. Feigin, Kristallografiya 29(3), 587 (1984).
L. A. Feigin and D. I. Svergun, Structure Analysis by Small-Angle X-ray and Neutron Scattering (Plenum Press, New York, 1987).
P. V. Konarev, V. V. Volkov, A. V. Sokolova, et al., J. Appl. Cryst. 36(5), 1277 (2003).
D. I. Svergun, J. Appl. Cryst. 25(Part 4), 495 (1992).
P. V. Konarev, M. V. Petoukhov, and D. I. Svergun, J. Appl. Cryst. 34(4), 527 (2001).
D. I. Svergun, C. Barberato, and M. H. J. Koch, J. Appl. Cryst. 28(Part 6), 768 (1995).
S. G. Skuridin, V. A. Dubinskaya, V. M. Rudoi, et al., Dokl. RAN 432(6), 838 (2010).
L. V. Zherenkova, P. V. Komarov, and P. G. Khalatur, Kolloid. Zh. 69(5), 753 (2007).
T. M. Herne and M. J. Tarlov, J. Am. Chem. Soc. 119(38), 8916 (1997).
D. Y. Petrovykh, H. Kimura-Suda, L. J. Whitman, and M. J. Tarlov, J. Am. Chem. Soc. 125(17), 5219 (2003).
W. J. Parak, T. Pellegrino, C. M. Micheel, et al., Nano Lett. 3(1), 33 (2003).
A. Kira, H. Kim, and K. Yasuda, Langmuir 25(3), 1285 (2009).
S. Link and M. A. El-Sayed, J. Phys. Chem. B 103(40), 8410 (1999).
K. H. Su, Q. H. Wei, X. Zhang, et al., Nano Lett. 3(8), 1087 (2003).
W. Rechberger, A. Hohenau, A. Leitner, et al., Opt. Commun. 220(1–3), 137 (2003).
P. V. Kamat, J. Phys. Chem. B 106(32), 7729 (2002).
J. J. Storhoff, A. A. Lazarides, R. C. Mucic, et al., J. Am. Chem. Soc. 122(19), 4640 (2000).
C. J. Loweth, W. B. Caldwell, X. Peng, et al., Angew. Chem. Int. Ed. 38(12), 1808 (1999).
A. Kumar, M. Pattarkine, M. Bhadbhade, et al., Adv. Mater. 13(5), 341 (2001).
H. Nakao, H. Shiigi, Y. Yamamoto, et al., S. Tokonami, Nano Lett. 3(10), 1391 (2003).
S.-J. Park, A. A. Lazarides, J. J. Storhoff, et al., J. Phys. Chem. B 108(33), 12375 (2004).
K. C. Grabar, P. C. Smith, M. D. Musick, et al., J. Am. Chem. Soc. 118(5), 1148 (1996).
N. G. Khlebtsov, L. A. Dykman, Ya. M. Krasnov, and A. G. Melnikov, Kolloid. Zh. 62(6), 844 (2000).
N. G. Khlebtsov, A. G. Melnikov, L. A. Dykman, and V. A. Bogatyrev, in Photopolarimetry in Remote Sensing, Ed. by G. Videen, Ya. S. Yatskiv and M. I. Mishchenko (Kluwer Acad. Publishers, Dordrecht, 2004), vol. 161, Part 5, pp. 265–308.
B. N. Khlebtsov, V. P. Zharov, A. G. Melnikov, et al., Nanotechnology 17(20), 5167 (2006).
J. Schmitt, G. Decher, W. J. Dressick, et al., Adv. Mater. 9(1), 61 (1991).
K. C. Grabar, R. G. Freeman, M. B. Hommer, and M. J. Natan, Anal. Chem. 67(4), 735 (1995).
E. Katz and I. Willner, Angew. Chem. Int. Ed. Engl. 43(45), 6042 (2004).
N. G. Khlebtsov, L. A. Dykman, Ya. M. Krasnov, and A. G. Melnikov, Kolloid. Zh. 62(6), 765 (2000).
Yu. M. Yevdokimov, S. G. Skuridin, V. I. Salyanov, et al., J. Biomater. Nanobiotechnol. 2(4), 461 (2011).
Yu. M. Yevdokimov, V. I. Salyanov, E. I. Kats, and S. G. Skuridin, Acta Naturae (in press).
B. K. Vainshtein, Diffraction of X-rays by Chain Molecules (Elsevier Publishing Company, Amsterdam-London-New York, 1966).
N. Khlebtsov and L. Dykman, Chem. Soc. Rev. 40(3), 1547 (2011).
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © Yu.M. Yevdokimov, E.V. Shtykova, V.I. Salyanov, S.G. Skuridin, 2013, published in Biofizika, 2013, Vol. 58, No. 2, pp. 210–220.
Rights and permissions
About this article
Cite this article
Yevdokimov, Y.M., Shtykova, E.V., Salyanov, V.I. et al. Linear clusters of gold nanoparticles in quasinematic layers of DNA liquid-crystalline dispersion particles. BIOPHYSICS 58, 148–156 (2013). https://doi.org/10.1134/S0006350913020061
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0006350913020061