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The effect of combined application of quercetin and indralin on postradiation repair of the hematopoietic system in acute radiation sickness

  • Radiobiology and Radioecology
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Abstract

Hybrid F1 mice (CBA × C57Bl/6) were subjected to irradiation at a nonlethal dose of 6.7 Gy that brought on acute radiation sickness. In the experiments performed, we observed the beneficial effect of combined application of quercetin injected 30–60 min prior to irradiation with γ rays and the emergent radioprotector indralin injected after irradiation on development of postradiation repair in hematopoietic tissue. This effect was expressed as accelerated formation of endogenous spleen colonies and recovery of spleen weight and attenuation of leucopenia 12 and 16 days after acute irradiation. Treatment with only quercetin was not radioprotective.

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Authors and Affiliations

  1. State Research and Test Institute of Military Medicine, Ministry of Defense of the Russian Federation, Moscow, Russia

    M. V. Vasin, I. B. Ushakov, V. Yu. Kovtun, S. N. Komarova, L. A. Semenova, L. V. Koroleva, A. A. Galkin & R. V. Afanas’ev

Authors
  1. M. V. Vasin
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  2. I. B. Ushakov
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  3. V. Yu. Kovtun
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  4. S. N. Komarova
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  5. L. A. Semenova
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  6. L. V. Koroleva
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  7. A. A. Galkin
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  8. R. V. Afanas’ev
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Correspondence to M. V. Vasin.

Additional information

Original Russian Text © M.V. Vasin, I.B. Ushakov, V.Yu. Kovtun, S.N. Komarova, L.A. Semenova, L.V. Koroleva, A.A. Galkin, R.V. Afanas’ev, 2011, published in Radiatsionnaya Biologiya. Radioekologiya, 2011, Vol. 51, No. 2, pp. 247–251.

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Vasin, M.V., Ushakov, I.B., Kovtun, V.Y. et al. The effect of combined application of quercetin and indralin on postradiation repair of the hematopoietic system in acute radiation sickness. BIOPHYSICS 56, 917–920 (2011). https://doi.org/10.1134/S0006350911050241

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  • DOI: https://doi.org/10.1134/S0006350911050241

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