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Modified peroxiredoxins as prototypes of drugs with powerful antioxidant action

  • Nanotechnologies in Medicine and Industry
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Abstract

The possibility of using modified peroxiredoxins as powerful antioxidant agents has been considered. Peroxiredoxins immobilized on perfluorocarbon emulsions and PTD-modified peroxiredoxins have been studied. It has been shown that peroxiredoxins efficiently bind to particles of perfluorocarbon emulsions, while maintaining their antioxidant properties. A panel of PTD-modified peroxiredoxins has been created and peroxiredoxins most effective both in antioxidant properties and the ability to penetrate cells have been selected. The modified peroxiredoxins obtained may serve as the basis for the design of drug with powerful antioxidant action.

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References

  1. I. V. Peshenko, V. I. Novoselov, Yu. V. Nikolaev, et al., Free Rad. Biol. Med. 25, 654 (1998).

    Article  Google Scholar 

  2. V. I. Novoselov, S. E. Amelina, I. N. Kravchenko, et al., Dokl. RAN 375,6, 831 (2000).

    Google Scholar 

  3. S. V. Novoselov, I. V. Peshenko, V. V. Popov, et al., Cell. Tissue. Res. 298, 471 (2001).

    Article  Google Scholar 

  4. A. G. Chuchalin, V. I. Novoselov, O. N. Shifrina, et al., Respiratory Medicine 97(2), 147 (2003).

    Article  Google Scholar 

  5. L. C. Clark and F. Gallon, Science 152(3730), 1755 (1996).

    Article  ADS  Google Scholar 

  6. R. P. Geyer, New Engl. J. Med. 289, 1077 (1973).

    Article  Google Scholar 

  7. J. M. Gump and S. F. Dowdy, Trends Mol. Med. 13, 443 (2007).

    Article  Google Scholar 

  8. C. L. Murriel and S. F. Dowdy, Expert Opin Drug Deliv. 3, 739 (2006).

    Article  Google Scholar 

  9. S. R. Cai, G. Xu, M. Becker-Hapak, et al., Eur. J. Pharm. Sci. 27, 311 (2006).

    Article  Google Scholar 

  10. J. S. Wadia and S. F. Dowdy, Curr Opin Biotechnol. 13, 52 (2002).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia

    V. I. Novoselov, V. K. Ravin, M. G. Sharapov, A. D. Sofin, N. I. Kukushkin & E. E. Fesenko

Authors
  1. V. I. Novoselov
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  2. V. K. Ravin
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  3. M. G. Sharapov
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  4. A. D. Sofin
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  5. N. I. Kukushkin
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  6. E. E. Fesenko
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Corresponding author

Correspondence to V. I. Novoselov.

Additional information

Original Russian Text © V.I. Novoselov, V.K. Ravin, M.G. Sharapov, A.D. Sofin, N.I. Kukushkin, E.E. Fesenko, 2011, published in Biofizika, 2011, Vol. 56, No. 5, pp. 873–880.

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Novoselov, V.I., Ravin, V.K., Sharapov, M.G. et al. Modified peroxiredoxins as prototypes of drugs with powerful antioxidant action. BIOPHYSICS 56, 836–842 (2011). https://doi.org/10.1134/S0006350911050137

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  • DOI: https://doi.org/10.1134/S0006350911050137

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