Abstract
Biophysicochemical approaches to the solution of nanotechnology problems associated with the design of functional biomimetic nanosystems, hybrid and composite nanobiomaterials and study of their structure-function relationships. The results of studies concerned with physicochemical mechanisms of the formation of organized biomimetic nanostructures and bioinorganic nanomaterials in systems involving a bulky liquid phase and the interface (gas-liquid, solid-liquid, liquid-liquid)during the synthesis and structure formation with the participation of the components of colloid systems, inorganic nanoparticles of various composition and clusters of metals, surfactants, polyelectrolytes and their complexes are discussed. In the development of the methods for the formation of composite bioinorganic nanosystems containing inorganic nanocomponents, two major approaches were used: adsorption and incorporation into the biomolecular matrix or colloid system of presynthesized inorganic nanoparticles, as well as the synthesis of the inorganic nanophase immediately in the biomolecular system. The methods of obtaining biomaterials and nanosystems are based on the principles of biomimetics, biomineralization, self-assembly and self-organization, combination and integration of a number of synthetic and physicochemical methods (physical and chemical adsorption, Langmuir technique, the formation of polycomplexes, chemical linking, competitive interactions, and substitution of ligands in supramolecular and coordination complexes) and nanocomponents of different nature. In particular, a novel approach to the preparation of highly organized nanofilm materials was developed, which is based on the effect of self-assembly and self-organization of colloid nanoparticles during the formation of their complexes with polyfunctional biogenic ligands in the volume of the liquid phase in the absence of any surfaces and interfaces. The physical and chemical factors responsible for the formation of structurally ordered biomolecular and composite nanosystems including nano-sized components of different nature and the possibilities to control the composition, structure, and properties of resulting nanomaterials and nanosystems are discussed. The experimental methods and approaches developed may be useful in studies of structure-property relationships and basic mechanisms of structural organization and transformation at the nanoscales level in biological, artificial, and hybrid nanosystems. The problems of practical application of the synthetic methods and the corresponding nanomaterials are discussed.
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References
M.-C. Daniel and D. Astruc, Chem. Rev. 104, 293 (2004).
S. P. Gubin, N. A. Kataeva, and G. B. Khomutov, Izv. RAN Ser. Khim., no. 4, 811 (2005).
S. P. Gubin, Yu. A. Koksharov, G. B. Khomutov, and G. Yu. Yurkov, Usp. Khimii 74(6), 539 (2005).
Nanobiotechnology: Concepts, Applications and Perspectives, Ed. by C.M. Niemeyer, C.A. Mirkin (C.H.I.P.S. Weimar, Texas, 2004).
Nanomaterials for Application in Medicine and Biology, Ed. by M. Giersig, G.B. Khomutov (Springer, Dordrecht, The Netherlands, 2008).
N. G. Khlebtsov, V. A. Bogatyrev, L. A. Dykman, and B. N. Khlebtsov, Ros. Nanotekhnol. 2(3–4), 69 (2007).
The Biomineralization of Nano- and Micro-strructures, Ed. by E. Bauerlein (Wiley-VCH, Weinheim, 2000).
Iron Biominerals, Ed. by R. B. Frankel, R. P. Blakemore (Plenum Press, New York, 1991).
S. Mann, Biomineralization: Principles and Concepts in Bioinorganic Materials Chemistry (Oxford University Press, New York, 2001).
Bio-inorganic Hybrid Nanomaterials, Ed. by E. RuizHitzky, K. Ariga, Y.M. Lvov (Wiley-VCH, Weinheim, 2007).
N. L. Rosi and C. A. Mirkin, Chem. Rev. 105, 1547 (2005).
W. J. Parak, D. Gerion, T. Pellegrino, et al., Nanotechnology 14, R15 (2003).
L. A. Bauer, N. S. Birenbaum, and G. J. Meyer, J. Mater. Chem. 14, 517 (2004).
I. Safarik and M. Safarikova, Chemical Monthly 133, 737 (2002).
A. K. Gupta and M. Gupta, Biomaterials 26, 3995 (2005).
G. B. Khomutov, Doctoral dissertation (MGU, 2006).
A. N. Tikhonov, G. B. Khomutov, E. K. Ruuge, and L. A. Blumenfeld, Biochim. Biophys. Acta 637, 321 (1981).
V. V. Prushenko, M. S. Gins, V. K. Gins, and A. N. Tikhonov, Fiziol. Rast. 49, 656 (2002).
G. B. Khomutov, S. A. Yakovenko, E. S. Soldatov, et al., Biol. Membrany 13, 612 (1996).
G. G. Roberts, Langmuir-Blodgett Films (Plenum Press, NY., 1990).
G. B. Khomutov, Adv. Colloid Interface Sci. 111, 79 (2004).
G. B. Khomutov and Yu. A. Koksharov, Adv. Colloid Interface Sci. 122, 119 (2006).
G. B. Khomutov, E. S. Soldatov, S. P. Gubin, et al., Thin Solid Films 327–329, 550 (1998).
G. B. Khomutov, L. V. Belovolova, V. V. Khanin, et al., Colloids and Surfaces A 198–200, 745 (2002).
A. Yu. Obydenov, S. P. Gubin, V. V. Khanin, et al., Colloids and Surfaces A 198–200, 389 (2002).
G. B. Khomutov, L. V. Belovolova, S. P. Gubin, et al., Bioelectrochemistry 55, 177 (2002).
G. B. Khomutov, V. V. Kislov, M. N. Antipina, et al., Microelectronic Engineering 69(2–4), 373 (2003).
V. Kislov, B. Medvedev, Yu. Gulyaev, et al., Intern. J. Nanosci. 6, 373 (2007).
A. A. Zubilov, S. P. Gubin, A. K. Korotkov, et al., Pis’ma ZhTF 21(5), 41 (1994).
E. S. Soldatov, V. V. Khanin, A. S. Trifonov, et al., Pis’ma ZhETF 64, 510 (1996).
S. P. Gubin, V. V. Kolesov, E. S. Soldatov, et al., Patent RU 2105386 (1998).
S. P. Gubin, V. V. Kolesov, E. S. Soldatov, et al., Patent RU 2106041 (1998).
S. P. Gubin, Yu. V. Gulayev, G. B. Khomutov, et al., Nanotechnology 13, 185 (2002).
Multilayer Thin Films. Sequential Assembly of Nanocomposite Materials, Ed. by G. Decher, J. B. Schlenoff (Wiley-VCH, Weinheim, 2003).
R. K. Iler, J. Colloid Interface Sci. 21, 569 (1996).
R. K. Iler, US Patent 3485658 (1969).
G. Decher, Science 277, 1232 (1997).
Yu. M. Lvov and G. B. Sukhorukov, Membr. Cell Biol. 11, 277 (1997).
W. Li, M. Xian, Z. Wang, et al., Thin Solid Films 386, 121 (2001).
T. A. Kolesnikova, D. A. Gorin, P. Fernandes, et al., Advanced Functional Materials 10, 1189 (2010).
A. M. Yashchenok, D. N. Bratashov, D. A. Gorin, et al., Advanced Functional Materials 20, 3136 (2010).
A. M. Yashchenok, D. A. Gorin, M. Badylevich, et al., Phys. Chem. Chem. Phys. 12, 10469 (2010).
S. Westgate, A. M. Vaidya, G. Bell, and G. Halling, Enzyme Microb. Technol. 22, 575 (1998).
M. E. Bobreshova, G. B. Sukhorukov, E. A. Saburova, et al., Biofizika 44, 813 (1999).
G. B. Sukhorukov, M. M. Montrel, A. I. Petrov, et al., Biosens. Bioelectron. 11, 913 (1996).
A. A. Dementiev, A. A. Baikov, V. V. Ptushenko, et al., Biochim. Biophys. Acta 1712, 9 (2005).
A. A. Dement’ev, A. A. Rakhnyanskaya, and G. B. Khomutov, Ros. Khim. Zh. 51, 136 (2007).
F. Vacha, M. Vacha, L. Bumbra, et al., Photosynthetica 38, 493 (2000).
J. F. Allen and J. F. Forsberg, Trends Plant Sci. 6, 317 (2001).
F. Caruso, E. Donath, and H. Mohwald, J. Phys. Chem. B 102, 2011 (1998).
E. Donath, G. B. Sukhorukov, F. Caruso, et al., Angew. Chem., Int. Ed. 37, 2201 (1998).
G. B. Sukhorukov, M. Brumen, E. Donath, and H. Mohwald, J. Phys. Chem. B 103, 6434 (1999).
F. Caruso, W. Yang, D. Trau, and R. Renneberg, Langmuir 16, 8932 (2000).
S. Westgate, A. M. Vaidya, G. Bell, and P. G. Halling, Enzyme Microb. Technol. 22, 575 (1998).
R. Rouillon, R. Sole, R. Carpentier, and J.-L. Marty, Sens. Actuators 26–27, 477 (1995).
R. Rouillon, J.-J. Mestres, and J.-L. Marty, Anal. Chim. Acta 311, 437 (1995).
E. V. Piletskaya, S. A. Piletsky, T. A. Sergeyeva, et al., Anal. Chim. Acta 391, 1 (1999).
M. T. Giardi, M. Kobilizck, and J. Masojidck, Biosens. Bioelectron. 16, 1027 (2001).
A. A. Yaroslavov, E. G. Yaroslavova, A. A. Rakhnyanskaya, et al., Colloids and Surfaces B: Biointerfaces 16, 29 (1999).
A. A. Yaroslavov, V. Ye. Koulkov, E. G. Yaroslavova, et al., Langmuir 14, 5999 (1998).
A. N. Tikhonov, G. B. Khomutov, and E. K. Ruge, Mol. Biol. 14, 1065 (1980).
C. Bouraa, P. Menub, E. Payanc, et al., Biomaterials 24, 3521 (2003).
A. Diaspro, D. Silvano, S. Krol, et al., Langmuir 18, 5047 (2002).
A. A. Dement’ev, A. Yu. Semenov, A. N. Tikhonov, and G. B. Khomutov, Patent RU 2326898 (2008).
G. B. Khomutov, Patent RU 2364472 (2009).
G. B. Khomutov, S. N. Polyakov, V. V. Volkov, et al., Ros. Nanotekhnol. 3(5–6), 13 (2008).
G. B. Khomutov, in: Nanomaterials for Application in Medicine and Biology, Ed. by M. Giersig and G.B. Khomutov (Springer, Dordrecht, The Netherlands, 2008), p. 39.
G. B. Khomutov and Yu. A. Koksharov, in Magnetic-Nanoparticles, Ed. by S.P. Gubin (WILEY-VCH, Weinheim, 2009).
G. B. Khomutov, Yu. A. Koksharov, V. V. Kislov, I. V. Taranov, Patent PCT WO/2008/105681 (2008).
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Original Russian Text © G.B. Khomutov, 2011, published in Biofizika, 2011, Vol. 56, No. 5, pp. 881–898.
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Khomutov, G.B. Biomimetic nanosystems and novel composite nanobiomaterials. BIOPHYSICS 56, 843–857 (2011). https://doi.org/10.1134/S0006350911050083
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DOI: https://doi.org/10.1134/S0006350911050083