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Functioning of macromolecular complexes at successive stages of gene expression as self-coordinated molecular machines

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Abstract

The results of systematic investigations devoted to the role of Drosophila melanogaster proteins SAYP and ENY2 in the regulation of different stages of gene expression are presented. Gene expression is a system of multistage processes involving preparation of the chromatin matrix, initiation of transcription, mRNA synthesis, as well as formation of mRNP particles, their export, and translation in the cytoplasm. Each of these stages involves a great number of factors presented usually by protein complexes consisting of different subunits. Analysis of the available evidence indicates that the transcription coactivators SAYP and ENY2 act in gene expression as cooperative nanoregulators, thereby determining the molecular mechanisms of coordination of the spatial and temporal characteristics of the processes implementing the genetic information.

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Authors and Affiliations

  1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 117984, Russia

    A. V. Brechalov & S. G. Georgieva

  2. Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

    D. Ya. Gurskii, S. G. Georgieva & Yu. V. Shidlovskii

  3. Centre for Medical Studies of the University of Oslo, Moscow, Moscow, 119334, Russia

    Yu. V. Shidlovskii

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  1. A. V. Brechalov
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  2. D. Ya. Gurskii
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  3. S. G. Georgieva
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  4. Yu. V. Shidlovskii
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Additional information

Original Russian Text © A.V. Brechalov, D.Ya. Gurskii, S.G. Georgieva, Yu.V. Shidlovskii, 2011, published in Biofizika, 2011, Vol. 56, No. 5, pp. 831–839.

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Brechalov, A.V., Gurskii, D.Y., Georgieva, S.G. et al. Functioning of macromolecular complexes at successive stages of gene expression as self-coordinated molecular machines. BIOPHYSICS 56, 803–809 (2011). https://doi.org/10.1134/S0006350911050034

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  • DOI: https://doi.org/10.1134/S0006350911050034

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