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Antiradical and NO-Inhibiting activities of β-hydroxy(ethoxy) derivatives of nitrous heterocycles

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Abstract

The antiradical and NO-inhibiting activities of β-hydroxy(ethoxy) derivatives of nitrous heterocycles (3-hydroxypyridine, 5-hydroxybenzimodazole, and 6-hydroxy(alkoxy)-benzothiazole) have been studied. The antiradical activity has been studied using a homogeneous hydrophilic chemiluminescent system, and the quenching constants (K i ) have been determined. For the most reactive compound, 4-methylthiobenzimidazolyl-3-hydroxypyridine, K i = 4.5 × 105 M−1. The NO-inhibiting activity was estimated on a model of the endotoxin shock of experimental animals using a spin trap of nitric oxide radicals based on complexes of iron with sodium diethyldithiocarbamate. It was found that the compounds at doses of 0.25–1 mmol/kg have both the inhibitory and stimulating action on the production of nitric oxide in the liver of animals. The results obtained suggest that some derivatives of nitrous heterocycles can be used as effective antioxidant preparations.

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References

  1. E. B. Men’shikova, V. Z. Lankin, N. K. Zenkov, et al., Oxidative Stress. Proxidiants and Antioxidants (Slovo, Moscow, 2006) [in Russian].

    Google Scholar 

  2. K. M. Dyumaev, T. A. Voronina, and L. D. Smirnov, Antioxidants in Prophylaxis and Therapy of CNS Pathologies (Izd. Inst. Biomed. Chem. RAMS, Moscow, 2005) [in Russian].

    Google Scholar 

  3. C. K. Sen, Biochem. Pharmacol. 55(11), 1747 (1998).

    Article  Google Scholar 

  4. L. D. Smirnov, in Chemical and Biological Kinetics. New Horizons (Khimiya, Moscow, 2005), pp. 102–129 [in Russian].

    Google Scholar 

  5. V. Ya. Varich, Biofizika 24(2), 344 (1979).

    Google Scholar 

  6. Y. Suzuki, S. Fujii, T. Tominaga, et al., Biochim. Biophys. Acta 1335(3), 242 (1997).

    Article  Google Scholar 

  7. A. G. Konoplyannikov, S. Ya. Proskuryakov, L. V. Shtein, et al., Byul. Eksperim. Biol. Med. 127(6), 648 (1999).

    Article  Google Scholar 

  8. G. I. Klebanov, Yu. O. Teselkin, I. V. Babenkova, et al., Vestn. RAMN, no. 2, 15 (1999).

  9. Yu. O. Teselkin, I. V. Babenkova, O. B. Lyubitskii, et al., Vopr. Med. Khim. 43, 87 (1997).

    Google Scholar 

  10. A. F. Vanin, P. I. Mordvintcev, and A. L. Kleschyov, Studia Biophys. 102(2), 135 (1984).

    Google Scholar 

  11. A. F. Vanin, A. Huisman, E. S. G. Stroes et al., Free Rad. Biol. Med. 30(8), 813 (2001).

    Article  Google Scholar 

  12. M. M. Tarpey and I. Fridovich, Circ. Res. 89(3), 224 (2001).

    Article  Google Scholar 

  13. A. V. Kozlov, B. Sobhian, and G. Costantino, Biochim. Biophys. Acta 1536(2–3), 177 (2001).

    Google Scholar 

  14. S. Glantz, Medicobiological Statistics (Praktika, Moscow, 1999) [in Russian].

    Google Scholar 

  15. H. Y. Tseng, S. H. Wu, W. H. Huang, et al., Bioorg. Med. Chem. Lett. 15(8), 2027 (2005).

    Article  Google Scholar 

  16. J. S. Borer and L. S. Simon, Arthritis Res. Ther. Suppl. 4, 14 (2005).

    Article  Google Scholar 

  17. K. Takeuchi, A. Yokota, A. Tanaka, and Y. Takahira, Dig. Dis. Sci. 51(7), 1250 (2006).

    Article  Google Scholar 

  18. A. M. Panico, P. Vicini, G. Massimo, et al., Inflammation 28(4), 231 (2004).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 119991, Russia

    L. D. Smirnov, Yu. V. Kuznetsov, T. N. Nosko & A. E. Dontsov

  2. Medical Radiological Center, Russian Academy of Medical Sciences, Obninsk, Kaluga Region, 249036, Russia

    S. Ya. Proskuryakov & V. G. Skvortsov

Authors
  1. L. D. Smirnov
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  2. Yu. V. Kuznetsov
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  3. S. Ya. Proskuryakov
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  4. V. G. Skvortsov
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  5. T. N. Nosko
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  6. A. E. Dontsov
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Corresponding author

Correspondence to Yu. V. Kuznetsov.

Additional information

Original Russian Text © L.D. Smirnov, Yu.V. Kuznetsov, S.Ya. Proskuryakov, V.G. Skvortsov, T.N. Nosko, A.E. Dontsov, 2011, published in Biofizika, 2011, Vol. 56, No. 2, pp. 316–321.

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Smirnov, L.D., Kuznetsov, Y.V., Proskuryakov, S.Y. et al. Antiradical and NO-Inhibiting activities of β-hydroxy(ethoxy) derivatives of nitrous heterocycles. BIOPHYSICS 56, 276–280 (2011). https://doi.org/10.1134/S000635091102028X

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  • DOI: https://doi.org/10.1134/S000635091102028X

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