Abstract
We have applied Monte Carlo track structure simulations to estimate relative biological effectiveness (RBE) of low-energy protons using biophysical modelling of radiation effects induced by exposure of V79 cells growing in mono-layer. The microscopic energy deposition in cell nucleus and sub-nucleus volumes was investigated in order to understand the reasons of enhanced biological effectiveness near Bragg peak. Theoretical estimations of RBE based on frequency/dose average lineal energy and calculated yields of initial DNA breaks were collated with experimental RBEM data. It was found: (1) dose average lineal energy for whole cell nucleus as a function of proton energy shows a distinct peak at 550 keV; (2) the peak values for subnucleus volumes are large compared with the whole cell nucleus; (3) the yield of complex DNA breaks correlates with experimental RBEM data.
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Khvostunov, I.K., Nikjoo, H., Uehara, S. et al. The consideration of biological effectiveness of low energy protons using biophysical modeling of the effects induced by exposure of V79 cells. BIOPHYSICS 55, 1067–1075 (2010). https://doi.org/10.1134/S0006350910060321
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DOI: https://doi.org/10.1134/S0006350910060321