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Biophysics

, Volume 55, Issue 6, pp 1054–1058 | Cite as

Autoimmune processes after long-term low-level exposure to electromagnetic fields part 4. Oxidative intracellular stress response to the long-term rat exposure to nonthermal RF EMF

  • Y. G. GrigorievEmail author
  • V. F. Mikhailov
  • A. A. Ivanov
  • V. N. Maltsev
  • A. M. Ulanova
  • N. M. Stavrakova
  • I. A. Nikolaeva
  • O. A. Grigoriev
Radiobiology and Radioecology

Abstract

Forty eight male Wistar rats with initial weight of 200–220 g were exposed to EMF of 2450 MHz frequency and 500 μW/cm2 intensity for 7 h daily over a period of 30 days. On the seventh and 14th days after completion of exposure to the long-term EMF, enzyme immunoassay revealed a significant increase in the amount of specific antibodies of the IgM and IgG classes against the compounds yielded by interaction of amino acids with nitric oxide and its derivatives; tryptophan metabolites; azelaic acid; small-chain fatty acids; small-chain hydroxylated fatty acids; and palmitic, myristic, and oleic acids.

Keywords

electromagnetic fields of microwave frequency immunoglobulins antibodies stress reactive oxygen species nitric oxide amino acids small-chain fatty acids kynurenine pathway 

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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  • Y. G. Grigoriev
    • 1
    Email author
  • V. F. Mikhailov
    • 1
  • A. A. Ivanov
    • 1
  • V. N. Maltsev
    • 1
  • A. M. Ulanova
    • 1
  • N. M. Stavrakova
    • 1
  • I. A. Nikolaeva
    • 2
  • O. A. Grigoriev
    • 1
  1. 1.Burnasyan Federal Medical Biophysical Center of RussiaMoscowRussia
  2. 2.Institute of ImmunologyFMBAMoscowRussia

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