Abstract
The antiamyloidogenic capacity of water-soluble nitroderivatives of fullerene C60: methyl ester of L-N-[(2-nitroglyceryl) fullerenyl] proline, methyl ester of L-N-[(2,3-dinitroglyceryl) fullerenyl] proline, and 2-nitroxyethyl ester of L-N-([2-(nitroxy) ethyl] fullerenyl) proline has been studied in vitro by high-resolution electron microscopy. It was shown that these fullerene C60 nitroderivatives are able to prevent the formation of amyloid fibrils by the brain Aβ(1–42)-peptide and muscle X-protein and to destroy mature fibrils. Electron microscopy is a promising method for selecting effective antiamyloidogenic drugs. The antiamyloidogenic activity of nanodimensional fullerene C60 nitroderivatives offers strong possibilities for creating a new nanotechnology for the therapy of amyloidoses.
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Original Russian Text © A.G. Bobylev, L.G. Marsagishvili, M.D. Shpagina, V.S. Romanova, R.A. Kotelnikova, Z.A. Podlubnaya, 2010, published in Biofizika, 2010, Vol. 55, No. 3, pp. 394–399.
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Bobylev, A.G., Marsagishvili, L.G., Shpagina, M.D. et al. Effect of nitroderivatives of fullerene C60 on amyloid fibrils of the brain Aβ(1–42) peptide and muscle X-protein. BIOPHYSICS 55, 353–357 (2010). https://doi.org/10.1134/S0006350910030024
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DOI: https://doi.org/10.1134/S0006350910030024